Cnemidocarpa bicornuta

From the New Zealand ascidian Cnemidocarpa bicornuta, the brominated phenylethylamine 29 has been isolated. It exhibits mild cytotoxicity to P-388 cells (IC50 46 pM) [42]. 

Marine tunicates are also a source of brominated tyrosine derivatives. The colonial ascidian Aplidium sp., which was collected in Australia, yielded the novel iodinated tyrosine alkaloids 1973-1975 (1819). Collections of Botryllus sp. and Botryllus schlosseri from the Philippines and the Great Barrier Reef, respectively, have afforded botryllamides A-D (1976-1979) (1820). A Palauan ascidian Botrylloides tyreum produces several new botryllamides, including the brominated botryllamide G (1980) (1821). The simple brominated tyramines 1981 and 1982 were isolated from the New Zealand ascidian Cnemidocarpa bicornuta (1822) and an Indonesian Eudistoma sp. ascidian (1823). 

Lindsay BS, Battershill CN, Copp BR (1998) Isolation of 2-(3 -Bromo-4 -hydroxyphenol) ethanamine from the New Zealand Ascidian Cnemidocarpa bicornuta. J Nat Prod 61 857... 

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