Both tested strains

The mechanical properties were evaluated by two sets of tensile measurements. Typical stress-strain curves are shown in Figure 4. The modulus and stress decrease with increasing aging time. Similar results are observed for all aging samples at all three temperatures. Both testing methods provided essentially the same tensile data at 400% extension. The scatter of the tensile data is due to the experimental error associated with the measurement. 

In the single study In which there is adequate information, McCann et al. (12) reported that atropine does not induce point mutations in the Salmonella/mlcrosome assay. The compound was tested at up to 5,000 pg/plate, both with and without metabolic activation, in test strains that can reveal both base-pair and frameshlft mutations. This negative result, however, does not In Itself provide sufficient Information to justify a conclusion about the genotoxlc potential of the compound. 

This paper presents the combined experimental/numerical investigation of the behaviour of fluid-filled plastic containers subjected to drop impact. Drop Impact experiments were conducted on original and modified bottles. During the test, strain and pressure histories were recorded at various positions. Tests were simulated numerically using the two-system FSI model. Both solid and fluid domains remain fixed during the calculations, i.e. a small-strain analysis was performed for the solid while an Eulerian fi-ame of reference was used for the fluid. This procedure was found to be simple, stable and efficient. Numerical results agreed well with experimental data, demonstrating the capability of the code to cope with this complex fluid-structure interaction problem. 

A short report demonstrated the absence of a reliable correlation between kiUing kinetics and normal laboratory tests for pristinamycin susceptibility testing of some pneumococci (42). Eight selected multiresistant clinical isolates and two reference pristinamycin-resistant Streptococcus pneumoniae strains were studied. Disk diffusion susceptibility and MICs were determined by the agar dilution method, and all clinical isolates appeared to be susceptible to pristinamycin, whereas the two reference strains were not. In contrast, time-kill experiments identified a limited bactericidal effect of pristinamycin in three clinical and both reference strains. These three strains had been classified as pristinamycin-resistant by the Vitek-II system, which uses a kinetic turbidimetric measurement of bacterial growth. Epidemiological information is hindered by the use of highly selected strains for the study. 

Such a situation might therefore put an additional strain on the different Quality Assurance units concerned. Consequently, it has to be ascertained that, irrespective of where the test sites are located, the written reports of Quality Assurance personnel must reach both test facility management and the Study Director. In other circumstances, where there may be no direct, organisational connection between the different parties concerned, i.e., in... 

The test strains include those that are able to detect both frameshift and base-pair mutations. 

Using the minimal inhibition concentration (MIC) data for nine different strains, two significant principal components could be obtained, accounting for 77.1% and 16.1%, respectively, of the data variance. The loading plot, i.e. a plot of the calculated principal components with respect to the descriptors, shows that the first component is mainly related to the seven cell-free test systems, while the second one represents the two whole-cell test results. In other words, much redundant information was obtained by measuring in nine test systems two would have been sufficient. This separation means that the potency in both test systems is governed by different physicochemical properties. 

The results in Figure 2 show the rankings as averaged over each of the two tests. It is noteworthy (data not shown) that both the strained and unstrained tests gave roughly the same amount of degradation, despite the shorter time of the former. Indeed, the correlation was such that the data did not differ by more than 1 ranking point between the two tests. 

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