Itraconazole Bosentan

AZOLES - ITRACONAZOLE ANTI HYPERTENSIVES AND HEART FAILURE DRUGS -VASODILATOR ANTIHYPERTENSIVES - bosentan Azole antifungals t bosentan levels Azoles inhibit CYP3A4 and CYP2C9 Monitor LFTs closely... 

Clinically important, potentially hazardous interactions with amiodarone, azithromycin, bepredil, bosentan, bretylium, cisapride, clarithromycin, disopyramide, erythromycin, erythromycin fluconazole, fluoxetine, fluvoxamine, grapefruit juice, indinavir, itraconazole, ketoconazole, metronidazole, miconazole, nefazodone, nilotinib, paroxetine, pimozide, probucol, procainamide, quinidine, quinine, ritonavir, saquinavir, sertraline, sotalol, SSRIs, terfenadine, troleandomycin, voriconazole, zileuton, ziprasidone... 

Clinically important, potentially hazardous interactions with azithromycin, bosentan, ciprofibrate, clarithromycin, clopidogrel, cyclosporine, erythromycin, fosamprenavir, fusidic acid, gemfibrozil, imatinib, itraconazole, lopinavir, niacin, quinine, red rice yeast, telithromycin, verapamil... 

Other potent CYP3A4 inhibitors (e.g. itraconazole) are expected to interact similarly to ketoconazole. However, because fluconazole (a moderate inhibitor of CYP3A4) also inhibits CYP2C9, another enzyme involved in the metabolism of bosentan, it is anticipated that it could cause even larger increases in bosentan levels. 

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