Bone tissue engineering biodegradable polymers

B. Sitharaman, X.F. Shi, X.F. Walboomers, H.B. Liao, V. Cuijpers, L.J. Wilson, A.G. Mikos, J.A. Jansen, In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for, bone tissue engineering, Bone, vol. 43, pp. 362-3Z0, 2008. 

Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27(18) 3413—3431... 

Holy, C. E., Davies, J. E., and Shoichet, M. S., Bone tissue engineering on biodegradable polymers preparation of a novel poly(lactide-co-glycolide) foam, in Biomaterials, Carriers for Drug Delivery and Scaffolds for Tissue Engineering, Peppas, N. A. et al., Eds., AIChE Press, New York, 1997, 272. 

Injectable nanocomposites of single-walled carbon nanotubes and biodegradable polymers for bone tissue engineering. Biomacromolecules, 1, 2237-2242. 

Sitharaman, B., Shi, X. F., Tran, L. A., Spicer, P. P., Rusakova, I., Wilson, L. J. Mikos, A. G. (2007) Injectable in situ cross-linkable nanocomposites of biodegradable polymers and carbon nanostructures for bone tissue engineering. Journal of Biomaterials Science - Polymer Edition, 18, 655-671. 

Amino acids are natural nutrients. Polymers derived from amino acids may have advantageous biocompatibility, as demonstrated by PLA. However, amino acid based polymers often do not have good material properties. They are often difficult to process into 3-D structure, and possess poor mechanical properties. Tyrosine-derived polymers have been developed in the Kohn group as biodegradable polymers, which have shown certain promising properties (56), and have been used for bone tissue engineering research (57). 

Xie, M., Wang, L., Ge, J., Guo, B., Ma, P.X., 2015. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniUne trimer for bone tissue engineering. ACS Appl. Mater. Interfaces 7, 6772—6781. 

No.l3, 2003,p.2287-93 NEW SYNTHETIC BIODEGRADABLE POLYMERS AS BMP CARRIERS FOR BONE TISSUE ENGINEERING... 

Starch-based biodegradable polymers have been widely investigated in bone tissue engineering. 

Cao Y, Ibarra C and Vacant J P, Tissue engineering of cartilage and bone . In Synthetic Biodegradable Polymer Scaffolds, ed. A Ataala, D J Mooney, J P Vacant and R Langer, Birkhauser, Boston, USA, 1997, 199-214. 

Many efforts have been made to improve the mechanical properties of PHB and PHBHV. The combination of osteoconductive properties of HAp with the processability of biodegradable polymer can overcome limitations induced by the brittleness and can widen the application potential in bone tissue engineering. 

---