Bone alkaline phosphatase

Fasting ultrafilterable calcium increased and serum bone alkaline phosphatase isoenzyme levels decreased, but only in those with calcium intakes < 600mg/d. [Pg.352]

A study in 500 Australian women (aged 40 to 80 years) has shown that higher isoflavone intakes are associated with higher concentrations of bone alkaline phosphatase, a short-term marker of bone formation and turnover. [Pg.386]

The effects of inhaled budesonide 800 micrograms/day and fluticasone 400 micrograms/day on bone metabolism, morning cortisol concentrations, and clinical parameters have been studied in eight asthmatic patients (107). There were no changes in serum and bone alkaline phosphatase, osteocalcin, carboxyterminal propeptide of type 1 procollagen, and urinary calcium and deoxypyridinoline concentrations over 6 months. The authors concluded that fluticasone is as effective as twice the dose of budesonide in controlling asthmatic symptoms, without adverse effects on bone metabolism. [Pg.80]

In 70 postmenopausal women with completely resected breast cancers who were disease-free after taking tamoxifen for 2—3 years, a switch to exemestane resulted in increases in serum bone alkaline phosphatase and the carboxy-terminal telopeptide of type I collagen and a fall in parathormone bone mineral density worsened (28). [Pg.160]

Tsai K-S, Jang M-H, Hsu S H-J, et al. Bone alkaline phosphatase isoenzyme and carboxy-terminal propeptide of type 1 procollagen in healthy Chinese girls and boys. Clin Chem 45 136-138,1999-Wharton B, Bishop N Rickets. Lancet 362 1389-1400, 2003. [Pg.334]

K5. Kress, B. C., Mizrahi, I. A., Armour, W., Marcus, R., Enkey, R. D., andSantora, A. C., Use of bone alkaline phosphatase to monitor alendronate therapy in individual postmenopausal osteoporotic women. Clin. Chem. 45, 1009-1017 (1999). [Pg.290]

V3. Van Hoof, V. O., Martin, M., Blockx, P., Prove, A., Van Oosterom, A., etal., Immunoradiometric method and electrophoretic system compared for quantifying bone alkaline phosphatase in serum. Clin. Chem. 41, 853-857 (1995). [Pg.294]

ALP T t T Elevations usually associated with cholestasis. Bone alkaline phosphatase... [Pg.621]

Many enzymes are glycoproteins, and variations in carbohydrate side chains are a common cause of nonhomogeneity of preparations of these enzymes. Some carbohydrate moieties, notably h/-acetylneuraminic acid (sialic acid), are strongly ionized and consequently have a profound effect on some properties of enzyme molecules. For example, removal of terminal sialic acid groups from human liver and/or bone alkaline phosphatase with neuraminidase greatly reduces the electrophoretic heterogeneity of the enzyme. [Pg.195]

Bouman AA, Scheffer PG, Ooms ME, Lips P, Netelenbos C. Two bone alkaline phosphatase assays compared with osteocalcin as a marker of bone formation in healtliy elderly individuals. Clin Chem 1995 41 196-9. [Pg.1946]

Broyles DL, Nielsen RG, Bussett EM, Lu WD, Mizrahi lA, NunneUy PA, et al. Analytical and clinical performance and characteristics of tandem-MP ostase, a new immunoassay for serum bone alkaline phosphatase. Clin Chem 1998 44 2139-47. [Pg.1946]

Duda RJ )r, O Brien JF, Katzman JA, Peterson JM, Mann KG, Riggs BL. Concurrent assays of circulating bone gla-protein and bone alkaline phosphatase effects of sex, age, and metabolic bone disease. J Clin Endocrinol Metab 1988 66 951-7. [Pg.1949]

HUl C, Cerrito M, Grafstein E, Rao S, Wolfert R. Development of the BAP Tandem-R assay for the specific detection of bone alkaline phosphatase in human serum. CHn Chem 1991 37 1019. [Pg.1952]

HiU CS, Wolfert RL. The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase. Clin Chim Acta 1989 186 315-20. [Pg.1952]

Jones RG, Dyson EH, Cook JA, Forbes MA, Cooper EH. The use of a two-site immunoradiometric assay for bone alkaline phosphatase in the investigation of renal bone disease. Clin Chem 1991 37 1067. [Pg.1953]

Kress BC. Bone alkaline phosphatase methods of quantitation and clinical utility. J Clin Ligand Assay 1998 21 139-48. [Pg.1954]

With old W, Schulte U, Reinauer H. Method for determination of bone alkaline phosphatase activity analytical performance and clinical usefulness in patients with metabolic bone disease and malignant bone diseases. Clin Chem 1996 42 210-7. [Pg.1965]

Combination of liver and bone alkaline phosphatases to which various amounts of intestinal alkaline phosphatase were added to provide mixtures 5, 6, and 7. [Pg.267]

L-phenylalanine, the percent inhibitions of human intestinal liver and bone alkaline phosphatases are 77, 8, and 10 (Table 4), respectively. [Pg.267]

Stevenson (S47) and Port and Van Venrooy (P14) were able to demonstrate alkaline phosphatase activity following agar-gel electrophoresis. This technique was further developed by Haije and DeJong (HI), who obtained characteristic separate bands for liver and bone alkaline phosphatases. Dymling (D24) applied the technique to pregnancy serum and placenta. [Pg.305]

The greater heat sensitivity of bone alkaline phosphatase as compared to that of liver, kidney, and intestine was first reported without comnaent by Moss and King (M36). The incubation periods (at 55°C and pH 7.0)... [Pg.307]

Starch-gel migration of bone alkaline phosphatase yields bands in locations that can be occupied by gastrointestinal juice alkaline phosphatase as well as by the enzyme of kidney, lung, and spleen. High heat sensitivity is a property of the alkaline phosphatase from these various sources. Hence findings based on starch-gel electrophoresis and heat sensitivity in themselves are not diagnostic of a bone source. [Pg.341]

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