Blue tongue virus

Rueda et al., 1999 Maranga et al., 2000b). This type of chimera is currently under development using HBV VLPs, yeast Ty particles, and blue tongue virus VLPs, as well as other polioviruses. 

Form-determining roles for viral structural proteins have been suggested for the inner core of blue tongue virus. In this case, 120 P3 subunits pack to form a T=2 icosahedral inner core (Grimes et al, 1998). This core is subsequently tiled by the P7 protein, which is arranged with T=13 symmetry. Thus, the P3 inner core provides a template surface that serves to control P7 polymerization. A similar case has been made for the alphavirus fusion proteins. These viruses, which consist of nucleoprotein... 

Hgure 10 Reconstructions of Blue tongue virus (BTV) and core-like particle obtained from frozen-hydrated specimens. (A) The surface representation of the outer shell of the reconstructed virus particle viewed along a threefold axis. The globular regions (VPS) are colored yellow and the sail-shaped spikes (VP2) are blue. Bars = 10 nm. (Reproduced from Hewat EA, Booth TF, and Roy P (1992) Journal of Structural Biology 109 61-69.) (B) The surface representation of the BTV core-like particle viewed down a threefold axis from outside the particle. Bar=nm. (Modified from Hewat EA, Booth TF, Loudon PT, and Roy P (1992) Virology 189 10-20.)... 

---