Blood-Brain Barrier Crossing Nerve Growth Factor Stimulators

Blood-Brain Barrier Crossing Nerve Growth Factor Stimulators 

Utility Stimulation of Neural Axons in Nerve Cells in the Treatment of Parkinson s disease 

Invention Significance Neurological diseases are associated with the 

Bromoacetic acid (3.99 mmol) dissolved in 30 ml CH2C12 was treated with diisoprop ylc arbodiimide (6.78 mmol) and after 30 minutes a white precipitate formed, which was removed by filtration. The filtrate was treated with 1-benzylpiperazine (5.82 mmol), then stirred 10 hours, and concentrated. The residue was purified by flash chromatography using CH2Cl2/EtOAc and the product isolated in 89% yield. 

Preparation of l-(4-benzyl-piperidin-l-yl)-2-/V-benzyl-/V-ethylamiiie-ethanone 

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I. Blood-Brain Barrier Crossing Nerve Growth Factor Stimulators... 

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