Blood and hemostasis

Blood platelets release ATP, ADP, serotonin, and other compounds and this plays an important role in thrombosis and hemostasy. To study the mechanism of the release, in vitro release of ATP was followed using the firefly luciferase luminescence method [124],... 

Cano A (2003) Blood flow and hemostasis. In Schneider HPG (ed) Menopause The State of the Art in Research and Management. Parthenon, London, pp 139-145... 

Adipose tissue, fat, is usually thought of as a metabolically sluggish energy reservoir and mechanical and thermal insnlator. It has proved to be much more than that. Adipose tissue influences the body weight, the inunnne response, the control of blood pressure, hemostasis, bone mass, and the fnnctions of thyroid and reproductive glands. It does these things largely on the basis of synthesis and release of a family of adipocyte peptide hormones. 

Following injury to blood vessels, hemostasis ensures that blood loss is minimized. Initially, thrombocyte activation leads to contraction of the injured vessel and the formation of a loose clot consisting of thrombocytes (hemostasis). Slightly later, the action of the enzyme thrombin leads to the formation and deposition in the thrombus of polymeric fibrin (coagulation, blood clotting). The coagulation process is discussed here in detail. 

Note Hemostasis refers to a complex homeostatic mechanism within blood and on blood vessels that serves to maintain the patency of vessels after injury, while preserving the fluidity of blood. 

Interaction and adhesion of biological surfaces are central considerations for other physiological conditions as well. Platelets, erythrocytes, the vascular endothelium and other tissues interact during thrombosis and hemostasis. Also, when erythrocytes come in contact with artificial surfaces, damage often occurs and blood trauma may result. Finally, the accumulation of cholesterol deposits on the interior walls of arteries is responsible for atherosclerosis. 

One of the most striking differences between protein-dominated substrates e,g., skin, tissue masses, and blood) and other solid, semi-solid, or liquid surfaces is in their wettability and adhesiveness with other materials. Work on the development of surgical adhesives based upon the poly(a-cyanoacrylates) used successfully in hemostasis for massive... 

Drugs affecting blood coagulation, fibrinolysis, and hemostasis... 

Enzyme inhibition is one of the ways in which enzyme activity is regulated experimentally or naturally. Most therapeutic drugs function by inhibition of a specific enzyme. Inhibitor studies have contributed much of the available information about enzyme kinetics and mechanisms. In the body, some of the processes controlled by enzyme inhibition are blood coagulation (hemostasis), blood clot dissolution (fibrinolysis), complement activation, connective tissue turnover, and inflammatory reactions. 

In medicine, a Bovie cautery device is an instrument used for electrosurgical dissection and hemostasis (stoppage of bleeding). It s like a soldering iron an electrical current is used to heat a treatment filament or a tip the tip becomes extremely hot and is then used to transfer heat to the tissue. The heat destroys the tissue or cuts the tissue if the tip is moved. The heat produced also stops any bleeding by burning small blood vessels. The device has limited use. It s not supposed to be used on the genitals. 

Shibata, S., and B. Kobayashi. 1978. Blood platelets as a possible source of creatine kinase in rat plasma and serum. Thrombosis and Hemostasis (Stuttgart) 39 701-706. 

Sanders, T.A.B., Vickers, M., and Haines, A.R, Effect on blood lipids and hemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men, Clin. Set, 61, 317, 1981. 

Alexander B (1978) Effects of plasma expanders on coagulation and hemostasis dextran, hydroxyethylstarch, and other macromolecules revisited. In Blood substitutes and plasma expanders. Liss, New York, pp 293-326 Alexander CS, Zievel L (1961) Fat infusion. Arch Intern Med 107 514-528 Allardyce DB (1982) Cholestasis caused by lipid emulsions. Surg Gynecol Obstet 154 641-647... 

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