Blocking the initiation phase

The human body deploys an array of enzymes that metabolise potentially toxic compounds derived from the environment. Phase I enzymes such as the 

The involvement of tobacco smoke carcinogens in the aetiology of lung cancer is conclusively established, but the role of specific chemical carcinogens as inducers of colorectal cancer is much less clear. Mutagenic pyrolysis products derived from cooked food have come under suspicion as possible 

In all these studies, isothiocyanates appeared to reduce the risk of neoplasia preferentially amongst persons genetically deficient in GSTTl and GSTMl. 

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