Bismuth pharmacology

Scarpignato C, Pelosini I Bismuth compounds for eradication of Helicobacter pylori Pharmacology and safety. Progr Basic Clin Pharmacol 1999 11 87-126. 

Pharmacology BSS appears to have antisecretory and antimicrobial effects in vitro and may have some anti-inflammatory effects. The salicylate moiety provides the antisecretory effect, while the bismuth moiety may exert direct antimicrobial effects against bacterial and viral enteropathogens. 

L. Jaenicke, Bismuth, A Survey of Pharmacological and Medical Uses , Mining and Chemical Products, London, 1950. 

Pharmacology and toxicology of organic bismuth, arsenic and antimony... 

Menge H, Gregor M, Brosius B, Hopert R, Lang A. Pharmacology of bismuth. Eur J Gastroenterol Hepatol 1992 4(Suppl 2) 41-7. 

Wormser, U. Nir, I. In Chemistry of Organic Arsenic, Antimony and Bismuth Compounds, Patai, S. Ed. Wiley New York, 1994 Chapter 18, Pharmacology and toxicology of organic bismuth, arsenic and antimony compounds, pp 715-723. 

A striking feature of the cellular effects of bismuth compounds in animals (and one shared only by lead) is the production of intranuclear inclusion bodies of up to 5 ixm in diameter (87), for example, in the tubular epithelial cells of the kidney. Electron probe microanalysis shows that these contain both Bi and S, and so could be a complex with a Cys-rich protein such as metallothionein. Bismuth is known to be a potent inducer of renal metallothionein synthesis, and pretreatment of animals with bismuth salts can prevent some of the toxic side effects induced by cisplatin (88). The role of metallothionein in the pharmacology of bismuth remains to be established, but the strong involvement of zinc, also an inducer of metallothionein synthesis, in the metabolism of skin cells, for example, may be related. Like several other elements of Group V, the development of the biological chemistiy of Bi is hampered by the lack of good physical properties, in particular of a well-behaved NMR isotope. 

Comparison of omeprazole and cimetidine in healing of gastric ulcers and prevention of recurrence in horses. Equine Veterinary Education 13 260-264 Nwokolo C U, Mistry P, Pounder R E 1990 The absorption of bismuth and salicylate from oral doses of Pepto-Bismol (bismuth salicylate). Alimentary Pharmacology and Therapeutics 4 163-169 Rabon E C, Reuben M A 1990 The mechanism and... 

Thompson L P, Burrow J A, Madison J R et al 1994 Effect of bethanechol on equine gastric motility and secretion. In Proceedings of the 5th Equine Colic Research Symposium, Athens, GA, p. 12 Tillman L A, Drake F M, Dixon J S et al 1996 Safety of bismuth in the treatment of gastrointestinal diseases. Alimentary Pharmacology and Therapeutics 10 459-467... 

Demir L. Han I. Mass attenuation coelEcients, effective atomic numbers and electron densities of undoped and differently doped GaAs and InP crystals. Atm. Nucl. Energy. 2009, 36, 869-873. Ferraz K. S. O. et al. Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes. European J. Med Chem.. 2012, 53, 98-106... 

Figure 9.1 Schematic drawings of classical platinum-, ruthenium-, gold-, and bismuth-based pharmacological agents.

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