Bis 4-fluorophenyl

Similarly prepared were the corresponding diphenyl, bis[4-methylphenyl], bis 4-hromophenyl], and bis[3-fluorophenyl] derivatives4. 

Dilithiation of the bis(3-fluorophenyl)ethane 6 with. vec-butyllithium proceeds regioselectively to allow formation of the phosphepin oxide 7. ... 

Fluoro-substituted silole-containing polymers were recently prepared by Suzuki polycondensation reaction using 2,5-dihydroxyboryl-l,l-dimethyl-3,4-bis(3-fluorophenyl)-silole or l,3-dibromo-5-fluoro-benzene as fluoro-containing monomers and 2,7-dibromo-9,9-dioctyl-fluorene or 2,5-dihydroxyboryl-l,l-dimethyl-3,4-bis(phenyl)-silole as co-monomers [221]. With a polymerization... 

Dihydroxy[ 1,1 -biphenyl]-2,2 -diyl)bis[(3-fluorophenyl)methanone, 549 (4,4 -Dihydroxy[l,r-biphenyl]-2,2 -diyl)bis[(4-fluorophenyl)methanone, 549... 

Chemical Name 1 -[Bis(4-fluorophenyl)methyl] -4(3-phenyl-2-propenyl)piperazine Common Name —... 

Chemical Name 8-[4,4-bis(p-fluorophenyl)butyl] -l-phenyl-1,3,8-triazaspiro[4.5] decan-4-one... 

Bis(4-fluorobenzoyl)phenol, 349 Bis(4-fluorophenyl)phenyl phosphine oxide (BFPPO), 345. See also BFPPO monomer Bis(haloaryl) sulfones, 364 Bishaloimides, 346... 

CN 6-[4-[bis(4-fluorophenyl)methyl]-l-piperazinyl]-A(,(V -di-2-propenyl-l,3,5-triazine-2,4-diamine... 

CN l-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol... 

Hsin, L.-W., Dersch, C.M., Baumann, M.H. et al. (2002) Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents chiral hydroxyl-containing derivatives of l-[2-[bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and l-[2-(diphenylmethoxy)ethyl]-4-(3-phe-nylpropyl)piperazine. Journal of Medicinal Chemistry, 45 (6), 1321-1329. 

Two molecules with comparable geometry in an asymmetric unit were found for 3,4-bis(4-fluorophenyl)-l,2,5-oxadiazole 2-oxide. The bond length of the dipolar N-O bond is 1.107 (7) A <2006AXEo4827>. In the molecule of 5-(6,7-dimethoxy-l,2,3,4-tetrahydroisoquinolin-2-yl)-4-phenyl-l,2,5-oxadiazole Ar-oxide, the six-membered heterocyclic ring has a flattened boat form. Intermolecular C-H- O hydrogen bonds link the molecules into dimers, which may be effective in the stabilization of the crystal structure <2006AXEo3130>. 

The 3,4-bis(4-fluorophenyl)-l,2,5-oxadiazole 2-oxide 324 was found as a side product in the synthesis of isoxazole derivatives (Scheme 82, method A) <2006AXEo4827>. Dimerization of 3- and 4-nitrobenzonitrile A-oxides gave corresponding 1,2,5-oxadiazole A-oxides (Scheme 82, method B) <1999MI111>. 

Synthesis of ( )-trans-6-[4,4-bis(4-fluorophenyl)-3-(1 -methyl- 1H-tetrazol-5-yl)-1 (E), 3-[2- uC]butadienyl-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one... 

The Schlenk tube was filled with bisphosphinite ligand, (1R, 3R, 5R, 6S)-3,6-bis [bis (4 -fluorophenyl) phosphinooxy] bicyclo[3.2.0]heptane (6.7 mg), degassed methanol (3 mL) and (COD)2Rh 1 BF4 (5.25 mg). The reaction mixture was stirred at room temperature until all the material was dissolved (10 15 minutes) giving an orange solution. 

Bis(dichloroboryl)benzene (6) is an important starting material which lends itself to facile derivatization. As shown by Piers, it cleanly reacts with bis(penta-fluorophenyl)zinc to afford the corresponding bidentate Lewis acid 13 (Scheme 7) The molecular structure of diborane 13 has been determined and is shown in Fig. 1. In this structure, the vicinal boron atoms are held at 3.26 A and from one another and seem to be ideally positioned to cooperatively interact with monoatomic anions. The fully fluorinated version of this bidentate Lewis acid has also been prepared. Original efforts focused on the use of 1,2-bis(dichloroboryl)tetrafluorobenzene 14 as a starting material (Scheme 8). This compound could be observed in the early stage of the reaction of trimeric perfluoro-o-phenylenemercury (4) with boron trichloride, but was found to be unstable toward condensation into 9,10-dichloro-9,10-dihydro-9,10-diboraoctafluoroanthracene 15. The successful synthesis of the fully fluorinated... 

D(p-F)PPAP (lOe) 6-bis(4-fluorophenyl)-phosphino-2-(pivaloylamino)pyridine, 3-D(p-MeO) PICon (11b) 3-bis(4-methoxyphenyl)phosphinoisoquinolone, 3-D(p-F)PICon (lid) 3-bis(4-fluorophenyi)phosphinoisoquinolone. 

Poly(arylene ether triazole)s have also been prepared by heterocyclic-activated displacement polymerization [36], The 1,2,4-triazole unit sufficiently activated, albeit weakly, aryl fluorides for nucleophilic displacement. Several 3,5-bis(4-fluorophenyl)-4-aryl-l,2,4-triazoles were polymerized with various bis-phenols to yield polymers with Tgs from 185 to 230 °C [36]. The 1,2,4-triazole unit appears to be one of the more weakly activating heterocycles towards nucleophilic substitution polymerization. 

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