Biotransformations multi-step

Multi-Step Enzyme Catalysis Biotransformations and Chemoenzymatic Synthesis Edited by Eduardo Garcia-Junceda... 

Oxidizing Enzymes in Multi-Step Biotransformation Processes... 

Multi-Step Biotransformation Processes Involving Oxidation... 

Currently, DSM uses biocatalysis, biotransformation, and fermentation technologies in addition to chemical methods to produce these specialties. To keep ahead of the competition and provide the best service to our customers, we use classical and/or advanced (gen)omics tools such as proteomics and metabolomics to make continuous improvements in the productivity and quality of our industrial workhorses. In the many cases where it is difficult - or impossible - to apply fermentation, we use (multi-step) biocatalysis to achieve our goal. Other in-house competences that are of growing relevance to the pharmaceutical area include the formu-... 

Some microbial pathogens can circumvent the defensive response of plants by biotransforming the antimicrobial stilbenoids in a multi-step oxidative detoxification process [106], Research has shown that the pathogenicity of B. cinerea strains is positively correlated with these fungi s production of blue-copper oxidases known as stilbene oxidases or laccases [127,128]. These enzymes are polyphenol oxidases capable of catalyzing the oxidation and polymerization of numerous phenolic substrates [129,130,131,132]. It has been shown that 1 is readily transformed in the presence of B. cinerea culture medium filtrates that contain laccases [107]. Recently, six resveratrol dimers (restrytisols A-C... 

Use a biological total synthesis by fermentation or multi step biotransformation (with growing cells, resting cells, multi-enzyme systems, genetically or metabolically engineered biocatalysts, etc). 

Garcia-Junceda, F. (ed.) (2008) Multi-Step Enzyme Catalysis, Biotransformations and Che-moenzymatic Synthesis, Wiley-VCH Verlag GmbH, Weinheim. 

Sheldon, R. A., in Multi-Step Enzyme Catalysis Biotransformations and Chemoenzymatic Synthesis, Garcia-Junceda, E., ed., Wiley-VCH, Weinheim, 2008, pp. 109-135. 

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