Biotin, recommended daily allowance

Deficiency can be due to two known genetic disorders of biotin metabolism or be induced by excess intake of avidin, which binds biotin and thus leads to poor absorption. Symptoms are alopecia, eczema around nose and mouth, conjunctivitis, hyperaesthesia, paraesthesia, depression, and muscle pain 29 The recommended daily allowance is 30 to 35 fig.112... 

The body s need for most vitamins is relatively low. The amounts needed to ensure the normal physiological function of humans is dependent on many factors such as age, sex, health status, lifestyle, eating habits and work-related activity. Many countries have recommendations for the daily intake of vitamins, which are continually revised in accordance with contemporary scientihc knowledge and dietary guidelines. Presently, Recommended Daily Allowances (RDAs) are set in the EU (upper number) and United States (lower number) as follows vitamin A (800/900 xg), vitamin D (5/15 xg), vitamin E (12/15 mg), vitamin K (75/120 xg), thiamine (1.1/1.2 mg), riboflavin (1.4/1.3 mg), niacin (16/16 mg), pantothenic acid (6/5 mg), vitamin Bg (1.4/1.3 mg), biotin (50/30 xg), folacin (200/400 (xg), vitamin Bj2 (2.5/2.4 xg) and vitamin C (80/90 mg). 

RECOMMENDED DAILY ALLOWANCE OF BIOTIN. It is difficult to obtain a quantitative requirement for biotin, for the reason that intestinal microflora make a significant contribution to the body pool of available biotin often humans excrete via the feces and urine considerably more biotin than they have ingested. However, the estimated safe and adequate intakes of biotin are given in the section on VITAMIN(S), Table V-5, Vitamin Table. 

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