Biotechnology genomics

M., Schwartz, E., Strittmatter, A., Vote, I., Gottschalk, G., Steinbuchel, A., Friedrich, B., and Bowien, B. (2006) Hydrogen-based biotechnology genome sequence of the bioplastic-produdng Knallgas bacterium Ralstonia eutropha H16. Nat. Biotechnol., 24,1257-1262. 

Biotechnology. Particular attention must be paid to the detection of DNA in all finished biotechnology products because of the possibiUty that such DNA could be incorporated into the human genome and thus become a potential oncogene. The absence of DNA at the picogram-per-dose level should be demonstrated in order to assure the safety of biotechnology products (157). 

Acknowledgments This is part of the activities of the VIRGIL European Network of ExceUence on Antiviral Drug Resistance supported by a grant (LSHM-CT-2004-503359) from the Priority 1 Life Sciences, Genomics and Biotechnology for Health and is supported by a grant from the FWO (no. G.0267.04). 

The need to develop new materials for electrophoretic analysis and macromolecular separations prompted by the needs of the human genome project and the rapidly advancing fields associated with biotechnology, advances in the development of new analytical instrumentation—especially capillary electrophoresis, and practical limitations of the media currently used for gel electrophoresis [73]... 

Advances in biochemical knowledge have illuminated many areas of medicine. Conversely, the study of diseases has often revealed previously unsuspected aspects of biochemistry. The determination of the sequence of the human genome, nearly complete, will have a great impact on all areas of biology, including biochemistry, bioinformatics, and biotechnology. 

Information flowing from the Human Genome Project is having major influences in fields such as proteomics, bioinformatics, biotechnology, and pharmacogenomics as well as all areas of biology and medicine. 

DOVE A (1999) Proteomics translating genomics into products Nature Biotechnology 17 233-7. 

Genomic and molecular tools have made great impacts on plant biotechnology and offer potential for manipulation of carotenoids as natural colorants and also for applications in human and animal health. While microbial and other non-plant systems have been successfully used, plant modification eliminates need for expensive bioreactors and offers economically feasible opportunities for less developed nations for production of nutraceuticals and other chemical products. 

Because the genome of E. sakazakii has not yet been sequenced and deposited into the National Center for Biotechnology Information (NCBI)... 

Zhu, D., Mukherjee, C., Biehl, E.R. and Hua, L. (2007) Discovery of a mandelonitrile hydrolase from Bradyrhizobium japonicum USDA110 by rational genome mining. Journal of Biotechnology, 129, 645-650. 

Zazopoulos, E., Huang, K., Staffa, A. et al. (2003) A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology, 21, 187. 

Oliynyk, M., Samborskyy, M., Lester, J.B. et al. (2007) Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nature Biotechnology, 25, 447-453. 

Corp. Cereon Genomics. Hybridon Proneuron Biotechnologies. 

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