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Biotechnology drugs nature

Marks, P.A. and Breslow, R. (2007) Dimethyl sulfoxide to vorinostat development of this histone deacetylase inhibitor as an anticancer drug. Nature Biotechnology, 25, 84-90. [Pg.218]

Finally, the most convincing evidence in support of the absolute safety of BST relates to attempts to develop natural bovine growth hormone as a human drug. Natural BST, extracted from cows, was investigated in the 1950s as a possible injectable treatment for human dwarfism. Bovine insulin used to be the source of human insulin until biotechnology provided a better alternative. Both bovine and human growth hormone have 191 amino acids however, 35% of the amino acids are different between the two species. After inject-... [Pg.114]

Shankar, G., Pendley, C., and Stein, K.E. (2007) A risk based hioanalytical strategy for the assessment of antibody immune responses against biological drugs. Nature Biotechnology, 25, 555 561. [Pg.234]

Hodgson, J. (2001). ADMET-turning chemicals into drugs. Nature Biotechnology, 19, 722. [Pg.1354]

The development of the biotechnology industry presents new and novel molecules derived from nature. The utilization of these molecules as pharmaceutical products presents an analytical challenge of a magnitude greater than ever confronted. The drug candidate and closely-related molecules have... [Pg.408]

Parikh, A., Gillam, E.M. and Guengerich, F.P. (1997) Drug metabolism by Escherichia coli expressing human cytochromes P450. Nature Biotechnology, 15, 784—788. [Pg.226]

In addition to chemical-based drugs, a range of pharmaceutical substances (e.g. hormones and blood products) are produced by/extracted from biological sources. Such products, some major examples of which are listed in Table 1.2, may thus be described as products of biotechnology. In some instances, categorizing pharmaceuticals as products of biotechnology or chemical synthesis becomes somewhat artificial. For example, certain semi-synthetic antibiotics are produced by chemical modification of natural antibiotics produced by fermentation technology. [Pg.1]

Walsh, G. 1999. Drug approval in Europe. Nature Biotechnology, 17, 237-240. [Pg.103]

Martin CR, Kohli P (2002). The emerging field of nanotube biotechnology. Nature Rev. Drug Discov. 2 29-37. [Pg.218]

Lawrence S. BUhon dollar babies— biotech drugs as blockbusters, Nature Biotechnology 25 380-382 (2007). [Pg.18]

Persidis A. Signal transduction as a drug-discovery platform. Nature Biotechnology 16 1082-1083 (1998). [Pg.52]

Yildirim MA, et al. Drug-target network. Nature Biotechnology 25 1119-1126 (2007). [Pg.52]

Source Butcher EC, Berg EL, Kunkel EX Systems biology in drug discovery, Nature Biotechnology 22 1253-1259 (2004). [Pg.79]

Larvol BL, Wilkwerson LJ. In silico drug discovery tools for bridging the NCE gap, Nature Biotechnology 16 33-34 (1998). [Pg.389]

Gullo VP, Hughes DE, Exploiting new approaches for natural product drug discovery in the biotechnology industry, DrugDiscov Today 2 281-286, 2005. [Pg.42]


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See also in sourсe #XX -- [ Pg.2746 ]




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