Drug discovery tools

Several excellent reviews have appeared recently (Condon et al. 2005 Huang et al. 2006 Koch and Narjes 2006 Meanwell et al. 2005 Neyts 2006 Shim et al. 2006 Wu et al. 2005), which summarize the development of agents to treat HCV infection. In this report we highlight the application of modem drug discovery tools and techniques to inhibit HCV replication by describing selected examples that have appeared recently in the scientific literature. 

Larvol BL, Wilkerson LJ. In silico drug discovery tools for bridging the NCE gap. Nature Biochemistry 16(Suppl) 33-34 (1998). 

A. Koepke, Proteomics - a new drug discovery tool, Bioworld 2001 (March), 3, 14-15. 

I would like to thank Drs. Eric M. Gordon, Mikhail F. Gordeev and Jeff Jacobs at Versicor and Mark Gallop at Affymax for their valuable contributions toward establishing combinatorial chemistry as a critical drug discovery tool. 

Evans WE, Guy RK. Gene expression as a drug discovery tool. Nat Genet 2004 36 214-5. 

The next 10 years will no doubt bring further technological advances and creative insights to improve the drug discovery process even further. This will keep HTS approaches as a mainstream drug discovery tool for years to come. 

Stocks M (2005). Intrabodies as drug discovery tools and therapeutics. Curr. Opin. Chem. Biol. 9(4) 359-365. 

The development of combinatorial biosynthetic strategies, in which components of different polyketide pathways are combined to generate new polyketides, has attracted interest as a new drug discovery tool. Extension of previous approaches focused on combinations of different polyketide synthase components to inclusion of pathways that generate different polyketide starter units provides an additional element of structural diversity. 

Bueno, J., 2012. Antitubercular in vitro drug discovery tools for begin the search. In Cardona, P.-J. (Ed.), Understanding Tuberculosis — New Approaches to Fighting Against Drug Resistance. InTech, Rijeka, Croatia, pp. 147—169. Available from http //dx.doi.org/10.5772/2477. 

In this chapter, we will first discuss the basic principles of DNA-templated organic synthesis, as it is the mechanistic foundations for DNA-encoded libraries then we will discuss the progressive development of DNA-templated libraries and the evolution into a novel drug discovery tool. We will also discuss the DNA-recorded library, which also encodes library molecules with DNA but is conceptually different. These discussions will naturally involve specific drug discovery programs in which these libraries were applied and finally, we will discuss the outlook of DNA-eneoded libraries in the future of drug discovery. 

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