Bioscavengers agents

Moore, D.H. (1996). Bioscavengers as antidotes for organophosphorus (OP) agents. In Proceedings of the 2nd CB Medical Treatment Symposium, July 7-12, 1996, pp. 330 9. Spiez, Switzerland. 

Curtin, B.F., Seetharam, K.I., Dhoieam, P., Gordon, R.K., Doctor, B.P., Nambiar, M.P. (2008). Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines. J. Cell. Biochem. 103 1054-35. 

These enzymes are promising for destruction of chemical weapons stockpiles, soil remediation, decontamination of materials, protective equipment, and water polluted by pesticides and nerve agents (Russel et al, 2003). In particular, phosphorothiolates such as VX are relatively resistant to PTE. Thus, oxidative cleavage of the P-S bond could be achieved by oxidases like laccases. These enzymes could be used in association with other OP-degrading enzymes for skin decontamination or in topical skin protection formulations. Though no work has been performed on combined action of oxidases and hydrolases, oxidation of P-bonded alkyl/aryl chains by oxidases is expected to alter enantio-selectivity of PTE for parent OPs, and therefore to improve the efficiency of catalytic bioscavengers. 

Cerasoli, D. M., Lenz, D. E. (2002/this issue). Nerve agent bioscavengers Protection with reduced behavioral effects. Military Psychology, 14, 121—143. 

Nerve Agent Bioscavengers Protection With Reduced Behavioral Effects... 

Bioscavenger Test Species Agent Protection (LD f Serum 7V,b Reference... 

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