Biorhythmicity

The direct transport of absorbed drugs into systemic circulation, effectively by-passing the first-pass effect of the liver and gastrointestinal tract Lower enzymatic activity compared to the gastrointestinal tract or liver Amenability to self-medication, which increases patient compliance Possibility of pulsatile delivery of some drugs to simulate the biorhythmic release of these drugs Lower risk of overdosage Achievement of controlled release... 

In this study the inverse UV-B / ozone relationship on longer time scales is investigated. This includes the long-term UV-B modulation caused by the ozone depletion and/or by the Quasi-Biennial Oscillation (QBO) in total ozone (Zerefos et al., 1998). This oscillation in UV-B is also of great importance because it provides a quasi-regular rhythm to many biological UV-B related processes, a QBO-biorhythm, with additional implications in atmospheric chemistry particularly in the tropics. 

Webb WB (1971) Sleep behavior as a biorhythm. In WP Colquehoun (ed) Biological rhythms and human performance. Academic Press, New York, 149-177... 

Relax to learn so go into exile. Our bodies respond to an inner clock called biorhythms. Burning the midnight oil works well for some people, but not everyone. 

Variable release the delivery system provides drug input at a variable rate, to match, for example, endogenous circadian rhythms, or to mimic natural biorhythms. 

Biorhythms Cyclic changes in biological functions, such as twenty-feur-hour cycles of waking and sleeping and secretion of certain hormones, and the monthly menstrual cycle in women. 

Belladonna (deadly nightshade), 131-34 Benadryl, 146 Benzedrine, 48 Benzene, 126 Benzodiazepines, 74, 76 Betel, 54 Biorhythms, 37 Blood, Benjamin Paul, 790 "Blues," 147 "Blue velvet," 147 Bodybuilding, 148-49 Brecher, Edward M, 214 Brompheniramine (Dimetanc , 146 Broiichodilators, 150—51 "Burn-outs," 167 Burroughs, William S., 16 Butyl nitrite, 130, 131... 

Pineal gland A tiny, light-sensitive organ in the center of the brain, also called the pineal eye or "third eye." In reptiles it controls changes in skin color. In humans it is a master gland of the endocrine system, probably regulating many biorhythms. 

Biorhythms and other physiological events in the brain result in episodic and circadian secretion of CRH from the hypothalamus. Tliis in turn elicits similar circadian variation in ACTH release. Secreted ACTH then stimulates cortisol production, which provides negative feedback inhibition to the CRH-ACTH axis. The secretion of CRH, a 41-amino acid peptide, is modulated by neuroendocrine, physical, and emotional factors. Besides CRH, other circulating factors can have an influence on the secretory dynamics of ACTH release. Antidiuretic hormone from the... 

W. Krzyzanski, A. Chakraborty, and W. J. Jusko, Algorithm for apphcation of Fourier analysis for biorhythmic baselines of pharmacodynamic indirect response models. Chro-nobiol Int 17 77-93 (2000). 

It should be noted that ha might range from a constant zero-order rate constant to complex functions responsible for irregular biorhythmic baseline profiles. Appreciation of these fundamental principles derives from the fact that both drugs and diseases alter normal biological cascades responsible for controlling the homeostasis of physiological systems. 

Grotsch, H., M. Hropot, E. Klaus, V. Malerczyk, and H. Mattenhermer. 1985. Enzymuria of the rat Biorhythms and sex differences. Journal of Clinical Chemistry and Clinical... 

FLOWING WITH NATURE MOVEMENT, BREATHING, AND BIORHYTHMS... 

Late afternoon— from 4 p.m. to 7 p.m.—is the time when most of us begin to shift from activity to inactivity. Whatever your daily schedule, start to notice how your biorhythms change over the course of the day, and begin to work with them rather than to override them, remembering that the more regular your schedule, the healthier your brain is likely to be. 

Malcolm scratched his head. Predicting the future seems unlikely, sort of biorhythms for the nineties. ... 

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