Bioprocessing crystallization

Li Wang, Xian-Xue Gan (2009) Biomolecule-functionalized magnetic nanoparticles for flowthrough quartz crystal microbalance immunoassay of aflatoxin Bl. Bioprocess Biosyst Eng 32 109-116... 

Alternatively, enzyme-catalyzed reactions may be performed in nonconven-tional media composed of microemulsions and liquid crystals [135]. The use of these systems, however, requires a great deal of knowledge of bioprocess engineering for the separation of the surfactant from substrate(s) and/or product(s). 

The downstream process is an integral part of any bioprocess, and it needs a keen focus for economical product recovery. In the case of lA, it can be easily crystallized via filtration at lower pH values, but this strategy fails to separate the by-product associated with lA, hence decreasing the final product quality. Further, certain organic acids, such as itatartaric acid, tend to colorize the white lA crystals or prevent polymerization reactions in corresponding... 

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