Bioprocesses optimization

Despite the high social relevance of infectious diseases and widespread use of animal cell lines in vaccine production, the application of even unstructured models for quantitative analysis and parameter estimation has not been common practice in bioprocess optimization. So far, research concerning influenza vaccine production in MDCK cell cultures has focused on the characterization of metabolism, growth of different cell lines and virus yields in various production systems [1,2]. 

Berkholz R, Guthke R (2001). Model based sequential experimental design for bioprocess optimization—an overview. Focus Biotechnol. 4 129-141. 

Schubert, J., Simutis, R., Dors, M., Havlik, I., Lubbert, A., Bioprocess optimization and control Application of hybrid modelling, J. Biotechnol. 1994 35, 51-68... 

Alkaloids bioprocess optimization genetic engineering engineering microbial culture plant cell/tissue culture... 

Vlassides, S., Ferrier, J.G. and Block, D.E., 2001, Using historical data for bioprocess optimization modeling wine characteristics using artificial neural networks and archived process information. Biotech. Bioengn. 73(l) 55-68. 

Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis... 

Keywords Bioprocess optimization Promoter 5-adenosyl-L-methionine... 

Table 16.1 The reported genetic and bioprocess optimization strategy for SAM production... 

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