Bioorganic interactions

Zsila F, Simonyi M, and Lockwood SF. 2003. Interaction of the disodium disuccinate derivative of meso-astaxanthin with human serum albumin From chiral complexation to self-assembly. Bioorganic Medicinal Chemistry letters 13(22) 4093 4100. 

It is reasonable to assume the effect of plant roots and tops on the soil would be the same. However, this is not the case. Plant roots profoundly affect the chemical characteristics of soil. Because they are in intimate contact with the soil, roots are constantly extracting nutrients and water from the soil and exuding materials into it. The intimate relationship, which includes physical, microbiological, biochemical, bioorganic, and chemical interactions between roots and soil, is illustrated in Figure 4.3. 

Wittmann V. Synthetic approaches to study multivalent carbohydrate-lectin interactions. In Schmuck C, Wennemers H, editors. Highlights in bioorganic chemistry. Weinheim Wiley-VCH 2004. pp. 203-213. 

In summary, our approach of using cyclopeptides with natural amino acids and 3-aminobenzoic acid subunits for the development of macrocydic receptors has afforded remarkably efficient hosts. The cation affinity of 4b, for example, exceeds that of many calixarene derivatives. Even more interesting is the high anion affinity of 5 in aqueous solution. By introdudng additional functional groups such as car-boxylates to the periphery of the cavity, we recently also obtained cydopeptides that interact with neutral substrates, for example, carbohydrates [25]. Our peptides therefore represent a versatile dass of artificial receptor that should prove useful in supramolecular and bioorganic chemistry. 

This book, Highlights in Bioorganic Chemistry, describes exciting recent advances in all the aspects of the field. Part 1 deals with Biomolecules and their Conformations. Chapters on the natural chemistry of RNA, of / -amino acids, on binding to DNA, on nucleic acid polymerases, on ribozymes and proteases, are concerned with using chemistry tools to help us understand biological chemistry. Part 2 deals with Non-Covalent Intermolecular Interactions. Here there is work on... 

The main focus of bioorganic chemistry is the understanding of the underlying molecular basis of biological processes. There principles are the same for any class of biomolecules. We have therefore subdivided the present book in terms of structure, molecular interactions and function of biomolecules, rather then by the more traditional subdivision by different classes of biomolecules. 

Targett NM, Ward JE (1991) Bioactive microalgal metabolites mediation of subtle ecological interactions in phytophagous suspension-feeding marine invertebrates. Bioorganic Mar Chem 4 91-118... 

Pocker, Y. Bioinorganic and bioorganic studies of liver alcohol dehydrogenase. Chem. Biol. Interact. 2001 130 383-393... 

In conclusion, the application of DFM and TFM to bioorganic chemistry has led to new information on how fluorinated compounds interact with enzymes, has provided novel 19F NMR biophysical probes for use in biochemistry, and has led to subtle structurally and electronically modified analogues of methionine with which to probe enzymes. The addition of several fluorine atoms to a simple structure such as methionine has certainly led to an interesting series of adventures in bioorganic chemistry. 

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