Biomimetic surfaces

Fig. 1.9 S urface pressure ( r)-area (A) isotherms obtained for a lipid mixture (DPPC POPG PA, 68 22 9 (by weight)), alone and with 10% (w/w) of either SP-C peptide or SP-C peptoid added. Results indicate that the addition of the SP-C mimics engenders biomimetic surface activity, as indicated by lift-off at a higher molecular area and the introduction of a plateau...

Abdoul-Aribi, N. and Livage, J. (2005) Gelatine thin films as biomimetic surfaces for silica particles formation. Colloids and Sufaces B-Biointerfaces, 44, 191-196. 

Adsorption of ions at surfaces has been one of the classical fields of interest in regard of catalysis and separation. Among various surfoces, Langmuir monolayers mimic the structure of cell membranes and hence these biomimetic surfaces are a model system that enables one to investigate surface phenomena analogous to the membrane surfoces [1,2]. 

Walz, D., Knoll, W., and Naumann, R.L.C. (2008) Electronic wiring of a multi-redox site membrane protein in a biomimetic surface architeemre. Biophysical Journal, 94, 3698-3705. 

There is no doubt tliat the field of electrochemistry and its continual progress can and will have a substantial impact on the future of medical devices. Devices continue to be scaled down in size, which will necessitate a greater understanding of corrosion processes. As analytical tools for the study of surface chemistry improve and become more widespread, and as nano-architectmed control permeates into the medical world, electrochemistry will be viewed as an economical, simple, yet powerful technique to modify and create biomimetic surfaces and medical devices. 

Quirk, R.A. et al., Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid). Biomaterials, 22, 865, 2001. 

Using terminally functionalized polymers such as asymmetric PEG molecules, furthermore biomimetic devices can be created. For example, amine reactive N-succinimidyl tartrate monoamine poly(ethylene glycol)-block-poly(D,L-lactic acid) (ST-NH-PEGxPLAy) as well as thiol-reactive polymers using 3-maleinimido propionate as a linker (see Figure 12) can be prepared in order to create biomimetic surfaces upon reaction with proteins or small adhesion peptides. 

Cui, YL., Di Qi, A., Liu, WG. et al. 2003. Biomimetic surface modification of poly(L-lactic acid) with chitosan and its effects on articular chondrocytes in vitro. Biomaterials 24 3859-3868. 

Mark K, Park J, Bauer S, Schmuki P (2010) Nanoscale engineering of biomimetic surfaces cues from the extracellular matrix. Cell Tissue Res 339 131-153... 

Kokubo T, Yamaguchi S. Biomimetic surface modification of metallic biomaterials. In Surface coating and modification of trwtallic biomaterials 2015. p. 219—46. 

Biomimetic surface/artrficial membrane Lipid bilayers Biosensors (85), drug characterization, diagnosis Worsfold et al. (2006), Kilian et al. (2007b), Cunin et al. (2007), Pace et al. (2012b), Mey et al. (2012)... 

M. Nosonovsky and B. Bhushan, Multiscale effects and capillary interactions in functional biomimetic surfaces for energy conversion and green engineering., Philos. Trans. A. 367,1511-39 (2009). 

Additionally, a polymer s effectiveness as a scaffolding material is dependent on its interaction with transplanted or host cells. Thus the polymer s surface properties should facilitate their attachment, proliferation, and (possible) differentiation. A strong cell adhesion favors the proliferation of cells, while a rounded morphology promotes their differentiation [46], The hydrophilic nature of some polymers promotes a highly wettable surface and allows cells to be encapsulated by capillary action [101]. Furthermore, cellular attachment and function on polymeric scaffolds may be enhanced by providing a biomimetic surface through the incorporation of proteins and ligands. 

Finally, it is expected that the continuous development of smart and biomimetic surfaces, for example, with cues that change by altering a given stimulus, will be of great importance as they will help to understand cell behavior in a dynamic environment, similar as the in vivo environment. 

Introduction Biomimetic Surface Modifications Growth Factor-Presenting Materials Biomimetic Hydrogels and Controlled Cell Interactions Composite Scaffolds Used to Mimic Specific Cellular Environments Scaffolds Mimicking the Structure of ECM Conclusions References... 

Zurcher, S., Wackerlin, D., Bethuel, Y., Malisova, B., Textor, M., Tosatti, S. and Gademann, K. (2006) Biomimetic surface modifications based on the cyanobacterial iron chelator anachelin. Journal of the American Chemical Society, 128,1064-5. 

For electrode (conductor/semiconductor) surfaces, mass transport can be controlled with a variety of experimental protocols and the interfacial flux is measured directly via the current response (measured as a function of potential, time, etc.) [1], This is not true of other interfaces, such as minerals and many biomimetic surfaces in contact with the solution. In these instances, fluxes have often been deduced in a convoluted time- and space-averaged manner by determining the accumulation/loss of material in a bulk phase as a function of time. This leads to a considerable loss of dynamic resolution. Furthermore, in some systems, mass transport between the bulk and the interface is difficult to estimate, leading to incorrect mechanistic interpretation, with major implications for practical applications, whether this concerns drug transport across cell membranes or the growth of crystals. 

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