Biomembranes experimental data

We will now illustrate the above rationale in application to the sodium channels of biomembranes. Since a sodium channel under physiological conditions obeys the independence principle, one has to conclude that yNa(Na) 1. Now, consider the case where all the sodium ions in the solution have been replaced with another type of cations. Without going into details of the treatment undertaken on the basis of the experimental data reported in Reference (96) and Eqs. (123)-(125), we will only cite the distribution coefficients and relative rate constants thus obtained (Table 2). 

As it is assured that the conformations generated with the Marcelja field are consistent with experimental data, the procedure employing the overlay method and the continuous Marcelja model is a powerful tool for preparation of the initial coordinates of biomembrane simulations. By applying a short molecular dynamics simulation to the initial coordinates prepared by this procedure, the long equilibration time necessary to obtain results consistent with experiments is well circumvented. 

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