BioMap

LEG altered cell-cell signaling and qualification to the BioMAP database... 

Houck KA, Dix DJ, Judson RS, Kavlock RJ, Yang J, Berg EL (2009) Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems. J Biomol Screen 14 1054-1066... 

Department of Chemistry and Chemical Biology and BioMaPS Institute for Quantitative Biology Rutgers University, Piscataway NJ 08854, USA... 

Kunkel, E. J., Plavec, I., Nguyen, D., Melrose, J., Rosier, E. S., Kao, L. T., Wang, Y., Hytopoulos, E., Bishop, A. C., Bateman, R., Shokat, K. M., Butcher, E. C., and Berg, E. L., (2004). Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMap analysis in complex human primary cell-based models. ASSAY Drug. Dev. Technol. 2 431-441. 

Figure 4.5 Consecutive processing of a dataset obtained from a whole-body rat section MALDi-MSi experiment, using the exchange data format imzML and four different imaging software packages. After opening the orthogonai TOF-MS imaging data set in the BioMap software it was converted to imzML format and imported into the software SpectViewer for...

MALDI images can be visualized using Biomap software package (free 3.7.4 version at http //www.maldi-msi.org) by loading the. img file (imaging MALDI-MS data). 

The ion images were saved using the export function of Biomap (File/Export/Image). The example ion images of sphingolipids in mouse brain of Tay-Sachs and Sandhoff disease model are shown in Fig. 7.4 (fccNote 12). 

Software for data analysis and scientific visnalization package for molecnlar image generation (e.g., Origin, Origin-Lab Corp., Northampton, MA, USA) ImageJ (NIH, available at http //rsb.info.nih.gov). Biomap (available at http //www.maldi-msi.org). 

BioMap 3.7.S.4 (by Dr. Markus Stoeckli, Novartis Institutes for BioMedical Research). 

D ion maps were reconstructed using BioMap 3.7.5.4. An example of results is shown in Fig. 14.3. 

Although the described method relates specifically to the QSTAR Elite Mass spectrometer, it can be easily adapted to most commercial instruments optimized for the analysis of low molecular weight compounds. The BioMap software supports all current commercial MALDI-MSI instruments. 

BioMap software (Novartis, Basel, Switzerland) available through the MALDI-MSI web site (www.maldi-msi.org) can also be used for the same purpose. The functionalities of these two programs are very similar. 

Cynthia J. Burrows, Professor, Department of Chemistry, University of Utah, 315 S. 1400 East, Rm. 2020, Salt Lake City, UT 84112-0850 USA Email burrows chem.utah.edu David A. Case, Professor, Department of Chemistry and Chemical Biology, and BioMaPS Institute, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854-8066 USA Email case biomaps. rutgers.edu... 

---