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Biology bromination

Decarboxylation occurs by the cyclic mechanism explained on p. 678 to give the enol of the product, which is brominated again by the biological brominating agent. [Pg.162]

Eosin [15086-94-9] (tetrabromofluorescein), C2QHgBi40, made by the bromination of fluorescein, is both a dye and an adsorption indicator. Eosin Y /7 7372-87-17, C2QH Br40 2Na, the disodium salt, is a biological stain. 475 -Dibromofluorescein [596-03-2], C2QH2QBr20, is used in D C Orange No. [Pg.298]

Adenosine, N -dimethyI-5 -0-methyI-2, 3 -0-isopropylidene-methylation, 5, 537 Adenosine, homocitrullyamino-biological activity, 5, 603 Adenosine, 1-isopentenyI-synthesis, 5, 594 Adenosine, 2 -0-methyI-occurrence, 5, 600 Adenosine, 2-phenyIamino-synthesis, 5, 590 Adenosine, 2, 3, 5 -tri-0-acetyl bromination, 5, 540 Adenosine-8-earboxylic acids synthesis, 5, 593 Adenosines, isopropylidene-synthesis, 5, 584... [Pg.513]

Isothiazole-4,5-dicarboxylic acid, 3-phenyl-dimethyl ester synthesis, S, 150 Isothiazole-5-glyoxylic acid ethyl ester reduction, 6, 156 Isothiazole-4-mercurioacetate reactions, 6, 164 Isothiazole-5-mercurioacetate reactions, 6, 164 Isothiazoles, 6, I3I-I75 acidity, 6, 141 alkylation, 6, 148 aromaticity, S, 32 6, 144-145 basicity, 6, I4I biological activity, 6, 175 boiling points, 6, I43-I44, 144 bond fixation, 6, 145 bond orders, 6, I32-I34 calculated, 6, 133 bromination, S, 58 6, 147 charge densities, 6, 132-134 cycloaddition reactions, 6, 152 desulfurization, S, 75 6, 152 deuteration, S, 70... [Pg.683]

Jansson, B., Andersson, R., and Asplund, L. et al. (1993). Chlorinated and brominated persistent organic compounds in biological samples from the environment. Environmental Toxicology and Chemistry 12, 1163-1174. [Pg.353]

Suggest syntheses for TMs (9) and (10) needed as intermediates TM (9) in the synthesis of brominated hydroxy benzoic acids and TM (10) in the synthesis of model compounds for studying biological mechanisms of ester hydrolysis,... [Pg.23]

Neilson AH (2003) Biological effects and biosynthesis of brominated metabolites. Handbook Environ Client 3R 75-204. [Pg.143]

On the analogy of the physicochemical relation, one was led to define a biological Hammett equation which related the equilibrium constant of the drug-receptor complex to the electronic a parameters of the substituents (e.g. chlorine, bromine, methyl, ethyl, hydroxyl, carboxyl, acetyl, etc.) of the drug molecule. Since the equilibrium constant of a drug-receptor complex is reflected by the biological activity, this led to the first extrathermodynamic relationship in QS AR ... [Pg.387]

Lundstedt-Enkel K, Johansson AK, Tysklind M, Asplund L, Nylund K, Olsson M, Orberg J (2005) Multivariate data analyses of chlorinated and brominated contaminants and biological characteristics in adult guillemot (Uria aalge) from the Baltic Sea. Environ Sci Technol 39(22) 8630-8637. doi 10.1021/es051118o... [Pg.310]

Biological degradation of different PBDE compounds in aerobic conditions reported the formation of hydroxylated PBDEs of lower bromination than the original pollutant [26-28, 30]. There is only one report about PBDEs degradation... [Pg.258]

Furuta, T., Wang, S. S. H., Dantzker, J. L., Dore, T. M., Bybee, W. J., Callaway, E. M., Denk, W. and Tsien, R. Y. (1999). Brominated 7-hydroxycoumarin-4-ylmethyls Photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proc. Natl. Acad. Sci. USA. 96, 1193-1200. [Pg.288]

No specific biologic marker/test is available for pulmonary agents as a class however, exposure to bromine might be indicated by detection of elevated bromide levels in serum (reference level is 50-100 mg/L), or if chlorine or bromine is released and they are detected in environmental samples. The case can be confirmed if laboratory testing is not performed because either a predominant amount of clinical and nonspecific laboratory evidence is present or an absolute certainty of the etiology of the agent is known. [Pg.270]

The isolation from a marine ascidian and subsequent structure determination of polycitone A (105) (Fig. 6) was first reported [52] by Kashman and coworkers in 1994. In this paper, the penta-O-methyl derivative was reported to inhibit the growth of SV40 transformed fibroblast cells at a concentration of 10 jtg/mL. Loya, Hizi and Kashman published [53] an extensive account of the biological activity of polycitone A in 1999 in which case inhibition of retroviral reverse transcriptases and cellular DNA polymerases was described. The isolation from an ascidian and structure determination of polycitone B (106) (Fig. 4) was subsequently reported [54] by Kashman and coworkers in 2000. Obviously, the presence of extensive bromination in both polycitone A and B make this family of compounds unique among the 3,4-diarylpyrrole natural products. [Pg.94]

In order to synthesize biologically relevant phosphonylimidazole 73, bromoimidazole 72 was derived from radical-initiated bromination of methyl l-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate (71) [56]. The thiomethyl group served to block the C(2) position, which would otherwise undergo preferential halogenation under these conditions. As expected, a variety of Arbusov-Michaelis reaction conditions failed even under forcing conditions. On the other hand, Pd-catalyzed phosphorylation of 72 with diethyl phosphite led to methyl-4-diethylphosphonyl-l-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate (73). After further manipulations, the desired phosphonic acid-linked aminoimidazoles, which resembled intermediates formed during purine biosynthesis, were accessed. [Pg.351]


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See also in sourсe #XX -- [ Pg.204 ]




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