Biologies functionality assessment

While an individual s phenotype can directly assess a clinical measureable biologic function of interest (e.g., whether an individual is a fast or slow metabolizer of a certain drug), phenotyping is often expensive and not readily adapted for routine clinical practice. Analysis of genetic information—genotyping—might prove to be more efficient and better able to be adapted to the individualization of drug therapy. 

N 145 "Polysaccharide Conformation. Part VI. Computer Model-Building for Linear and Branched Pyranoglycans. Correlations with Biological Function. Preliminary Assessment... 

There are many techniques that can be employed to assess the immuno-genicity of a vaccine candidate, and laboratories interested in pursuing this objective should also explore other assays suited to their purposes. In this model, vaccine immunogenicity is measured by determining levels of anti-LHRH antibodies induced in mice immunized with lipopeptide or a nonlipi-dated peptide control. It is important to correlate vaccine immunogenicity with biological function, and we measure the reproductively capability of vaccinated female mice as an indication of vaccine efficacy. Techniques that determine testosterone and oestrogen levels are also useful. 

In the field of biology, the effects of hydration on equilibrium protein structure and dynamics are fundamental to the relationship between structure and biological function [21-27]. In particular, the assessment of perturbation of liquid water structure and dynamics by hydrophilic and hydrophobic molecular surfaces is fundamental to the quantitative understanding of the stability and enzymatic activity of globular proteins and functions of membranes. Examples of structures that impose spatial restriction on water molecules include polymer gels, micelles, vesicles, and microemulsions. In the last three cases since the hydrophobic effect is the primary cause for the self-organization of these structures, obviously the configuration of water molecules near the hydrophilic-hydrophobic interfaces is of considerable relevance. 

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta. Drug Metabolism and Disposition The Biological Fate of Chemicals, 33, 94—101. 

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