Biological space exploring

However, during the last 10 years, several groups have developed miniature and mobile mass spectrometers. Although these instruments were built for environmental applications, detection of chemical and biological weapons, and space exploration, most of them can easily be converted to detection of explosives. 

This section of Principles of Medicinal Chemistry concerns itself primarily with the issues surrounding the exploration of chemical space, including the relationship between chemical and biological space, stereoselectivity of drug interaction, privileged structures, structure-function relationships, selectivity and non-selectivity of drug action... 

Knowledge-driven approaches to explore matches of chemical and biological spaces... 

Fig. 15.1-3 Schematic visualization of the various concepts to address chemical and biological space (shaded areas) in drug discovery. Medicinal chemistry focused on compound series (red dots) that had shown activity in pharmacological assays and compound optimization was driven by a tight feedback from biological experiments, leading to a focused nonarrayed addressing of chemical space. The combinatorial promise was to systemically explore the chemical space with diverse arrays of compounds (blue dots) to find the suitable starting points. Analysis of combinatorial chemistry libraries showed their limited...

To that end, procedures and quahty control methods have been developed that are applicable in other situations too. Glean room technology that is essential for maximizing usable chip production is equally valuable in biological research and medical treatment facilities, applied physics laboratories, space exploration, aeronautics repair and maintenance facilities, and any other situations in which steps to protect either the environment or personnel from contamination must be taken. 

Polstra, S., Pronk, T. E., Pimentel, A. D., Breit, T. M. (2008). Towards design space exploration for biological systems. CIRP Journal of Computers, 3(2), 1-9. 

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