Biological recognition sites

Sialic acids masking biological recognition sites... 

In addition to this more general function, sialylation can mask specific biological recognition sites and, by reversible sialylation, can control biological events such as the action of hormones, ion channels, growth and ageing, some examples of which will be discussed in the following. 

Elucidation of the stmctural requirements for dmg interaction at the recognition site is by the study of stmcture—activity relationships (SAR), in which, according to a specific biologic response, the effects of systematic molecular modification of a parent dmg stmcture are determined. Such studies have permitted the classification of discrete classes of pharmacological receptors. For example, the neurotransmitter acetylcholine acts at both peripheral and central receptors which are of at least three distinct types. The effects of acetylcholine are mimicked in smooth and cardiac muscles and secretory... 

More recently, the more subtle modification techniques of site-directed mutagenesis have been applied to the problem of biological recognition of redox proteins. While the results are consistent with the previous electrostatic models. 

Now it would make no sense at all to have the insnhn receptor turned end for end in a biological membrane. That would put the insulin recognition site on the inside on the cell, where it would be useless, and the intracellular domain with its kinase activity on the ontside, where it would be equally useless. It follows that aU insulin receptors have the same, specific orientation with respect to the bilayer leaflets, with the receptor site adjacent to the exoplasmic leaflet and the kinase site adjacent to the cytoplasmic leaflet. 

Polymer-mediated self-assembly of nanoparticles provides a versatile and effective approach for the fabrication of new materials. This bottom-up strategy builds up nanocomposite materials from diverse nanosized building blocks by incorporation of molecular-level recognition sites. The flexibility and reversibUity of self-assembly processes imparted by specific molecular interactions facilitates the formation of defect-free superstmctures, and it can be further explored in fields ranging from electronics to molecular biology. 

Sphingolipids at Cell Surfaces Are Sites of Biological Recognition... 

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