Biological rank-ordered

The biologic actions of kinins are mediated by specific receptors located on the membranes of the target tissues. Two types of kinin receptors, termed Bj and B2, have been defined based on the rank orders of agonist potencies. (Note that here stands for bradykinin, not for -adrenoceptor.) Bradykinin displays the highest affinity in most B2 receptor systems, followed by lys-bradykinin and then by met-lys-bradykinin. One exception is the B2 receptor that mediates contraction of venous smooth muscle this appears to be most sensitive to lys-bradykinin. Recent evidence suggests the existence of two B2-receptor subtypes, which have been termed B2A and B2B. 

Rank-order compounds by properties for subsequent in vivo tests Interpretation of biological activity tests Provide feedback for property optimization... 

The biological effects of clay minerals are influeneed by their mineral eomposition and particle size. The decreasing rank order of the potencies of quartz, kaolinite, and montmorillonite to produee lung damage is consistent with their known relative active surfaee areas and surfaee chemistry. Biodegradations are variable in nature, owing to different types of clay. 

According to the nature of the activity data, QSAR studies can be divided into continuous (activities, i.e., response variable, takes many different values from within some interval), category (activities are represented by ranks or ordinal numbers), and classification (activities are different types of biological properties which cannot be rank ordered) approaches. 

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