Biological processes platelet aggregation

Oleuropein appears to interfere with some biological processes such as lipoprotein oxidation, platelet aggregation, platelet and leukocyte eicosanoid production and cardiovascular control too. As previously described, oleuropein and hydroxy-tyrosol are characterised by a catechol moiety that appears to be needed for their scavenger and antioxidant activities. In fact, it was demonstrated that these compounds prevent thermally initiated autoxidation of methyl linoleate in homogenous solutions [56], protect LDL from oxidation [57] and inhibit production of... 

Numerous in vivo studies have indicated that flavanols have diverse biological activities including antioxidant activity [7-11] and anticancer properties [12-14]. Flavanols may inhibit platelet aggregation as well as other vascular and inflammatory processes that contribute to disease [15-17]. These effects are thought to be mediated by changes in eicosonoid synthesis after consumption of flavanol-containing foods [9,18]. Flavanol metabolites isolated from urine were shown to reduce monocyte adhesion to endothelial cells in the inflammatory... 

In 1979, the chemical structure of PAF was identified as l-alkyl-2-acetyl-sn-gIycero-3-phosphocholine (Fig. 2) (D.J. Hanahan, 1979 M.L. Blank, 1979 J. Benveniste, 1979). The semi-synthetic preparation tested in these initial experiments aggregated platelets at concentrations as low as 10 " M and induced an anti-hypertensive response when as little as 60 ng were administered intravenously to hypertensive or normotensive rats. Threshold concentrations vary by cell type and organism, but PAF can activate human inflammatory cells at concentrations as low as 10 M. PAF induces diverse biological responses (Table 1) and has been implicated as a contributing factor in the pathogenesis of such diverse disease processes as asthma, hypertension, allergies, inflammation, and anaphylaxis. 

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