Biological colloids blood

A lot of natural as well as technological objects of analytical control are colloidal systems, i.e. human blood, biological liquids, sol and suspension forming in different technological processes (ore-dressing, electrochemical deposition, catalysis and other), food, paint-and-lacquer materials, sewage water and other. 

The distribution pattern of intravenously-injected Thorotrast in animals is similar to the pattern in humans most of the Thorotrast is taken up by the RES (Guimaraes et al. 1955 McNeill et al. 1973 Reidel et al. 1979). Reidel et al. (1979) determined that the average percent distribution of Thorotrast in the liver was within one order of magnitude in mice, rats, rabbits, dogs, and humans. The amount of thorium in the spleen of all species, except mice, was clearly below that in humans. Only 50% of the thorium in rats was retained in the liver and spleen, while approximately 85% was retained in humans. Direct comparison of the species is difficult, since the data were taken from other authors and analyzed by Reidel et al. (1979). The study concluded that the biological behavior of colloids was similar in humans and animals. Kaul and Heyder (1972) reported an extremely low rate of clearance of the colloid form from the blood about 1 hour after intravenous injection in rabbits. Subsequently, an increase in the rate of disappearance from the blood of the colloid form (biological half-life of 90 minutes) and of the soluble form (biological half-life of 75 minutes) was found. After 3, 6, or 12 hours, 23, 45, or 60% of the injected amount, respectively, was located in the liver. 

Once the microsphetes begin to jump about in Brownian movement in the solution, some of them collide with each other. What should happen when two approximately 105-cm metal spheres collide Many aspects of colloidal chemistry— and hence of molecular biology, including the electrochemical basis of the stability of blood and the forming of clots—are illuminated by a consideration of this subject. 

Zone electrophoresis is mostly used for biological applications. Peptide separation and the measurement of protein fractions from blood serum (proteinogram of albumin and o-, (3- and 7-globulins) are among the better known applications. This TLC for biochemists is useful for the separation of polysaccharides, nucleic acids (for DNA sequencing), proteins and other colloidal species. 

J. F. McClendon, R. Rufe, J. Barton, and F. Fetter, "Colloidal Properties of the Surface of the Living Cell 2. Electric Conductivity and Capacity of Blood to Alternating Currents of Long Duration and Varying in Frequency from 260 to 2,000,000 Cycles per Second," Journal of Biological Chemistry, 69 (1926) 733-754. 

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