Biological agents proteins

A small-molecule inhibitor of tumor necrosis factor a, a protein involved in inflammatory diseases such as rheumatoid arthritis, has been identified <2005SCI1022>. Direct inhibition by the commercial biological agents Enbrel and Remicade has produced major advances in rheumatoid arthritis treatment and validated extracellular inhibition of this proinflammatory cytokine as an effective therapy. The new inhibitor 35 is composed of trifluoromethylphenyl indole and dimethylchromone moieties linked by a dimethylethylenediamine spacer. 

The production of biologically important proteins by recombinant DNA techniques and development of modified counterparts is a very challenging field. Certain criteria of safety, quality, and efficacy are required for the development and approval of these protein products as therapeutic agents. The presence of structural variations during the different steps in the protein... 

All kinds of chemical substances behave as ionophores, such as chelates, crown ethers, biological agents, enzymes, microbes and specific proteins, and animal and plant whole tissues. 

In addition to symptoms and physical findings, diagnostic clues for inhalational exposure may include bilateral pulmonary infiltrates on chest X-ray, arterial hypoxemia, neutrophilic leukocytosis and a bronchial aspirate rich in protein compared to plasma, characteristic of high permeability pulmonary edema (39). Unlike many biologic agents, ricin intoxication wonld progress despite treatment with antibiotics. 

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