Biological activity 3.4- dihydro

Rueping, M., Antonchick, A. P, Sugiono, E., Grenader, K. (2009). Asymmetric Brpnsted acid catalysis catalytic enantioselective synthesis of highly biologically active dihydro-quinazoUnones. Angewandte Chemie International Edition, 48, 908-910. 

Folic acid, 4-amino-4-deoxy-10-methyl-, 1, 164 3, 325 as anticancer drug, 1, 263 biological activity, 3, 325 Folic acid, 4-amino-10-methyl-toxicity, 1, 141 Folic acid, 7,8-dihydro-biosynthesis, 3, 320 synthesis, 1, 161, 3, 307 Folic acid, 4-dimethylamino-hydrolysis, 3, 294 Folic acid, 5-formiminotetrahydro-biological activity, 3, 325 Folic acid, 5-formyl-5,6,7,8-tetrahydro-biological activity, 3, 325 chirality, 3, 281 occurrence, 3, 325 Folic acid, 10-forfnyltetrahydro-biological activity, 3, 325 Folic acid, 5,10-methenyl-5,6,7,8-tetrahydro-biological activity, 3, 325 chirality, 3, 281 Folic acid, 5-methyl-chirality, 3, 281 Folic acid, 9-methyl-toxicity, 1, 141... 

Furo[2,3-amino-synthesis, 4, 986 Furo[3,4-d]pyrimidinedione synthesis, 4, 987 Furopyrimidines, 4, 986 Furo[2,3-d]pyrimidines synthesis, 4, 986 Furo[3,2-d]pyrimidines synthesis, 4, 987 Furo[3,2- 6]pyrone synthesis, 4, 994 Furo[3,2-c]pyrone synthesis, 4, 993 Furo[3,2-6]pyrrole, hexahydro-biological activity, 6, 1024 1 H-Furo[3,4-6]pyrrole-2,3-dione, 4,6a-diphenyl-6-(phenylimino)-6,6a-dihydro-synthesis, 6, 1004 Furopyrroles... 

Imidazo[2,l-6]thiazole, 3-aryl-5,6-dihydro-biological activity, 6, 1024 Imidazo[2,l-6]thiazole, 5,6-bis(4-... 

H-Imidazo[2,l-6]thiazolium chloride, 6,7-dihydro-3-(5-nitro-2-furanyl)-biological activity, 6, 1024 5H-Imidazo[2,l-6]thiazolium salts, 6,7-dihydro-synthesis, 6, 992... 

Purine, 2-chloro-8-thioxo-7,8-dihydro-synthesis, 5, 578 Purine, 6-cyano-reactions, 5, 548 synthesis, 5, 593 Purine, 8-cyano-reactions, 5, 548 Purine, 8-deoxyribosyl-synthesis, 5, 585 Purine, 2,8-dialkyl-synthesis, 5, 568 Purine, 2,6-diamino-biological activity, 5, 604 reactions... 

Pyrido[3,4-d]pyridazine, 1,4-dimorpholino-biological activity, 3, 261 Pyrido[4,3-c]pyridazine, dihydro-NMR, 3, 234 UV spectra, 3, 236... 

Thieno[3,4-d]isothiazole, 2,3-dihydro-3-oxo-1,1-dioxide, 6, 989 biological activity, 6, 1024 Thieno[2,3-c]isothiazole-3-carboxylic acid synthesis, 6, 1023... 

Benzoyl-2,3-dihydro-lH-pyrrolizine-l-cai boxylic acid (ketorolac, L ) and 2-(3-benzoyl-phenyl)propionic acid (ketoprofen, L ) ai e biologically activ ligands used in medicine as non-steroidal anti-inflammatory dmgs. 

Lee D-S, Lee SH. Biological activity of dihydro tanshinone I effect on apoptosis. J Biosci Bioeng 2000 89 292-293. 

The second chapter Synthesis and Biological Activity of 2,5-Dihydro-1,2-Oxaphosphole-2-Oxide Derivatives deals with the recent synthetic methods, particularly those using phosphorylated allenes as the starting materials, of these compounds which show interesting biological properties. 

Abstract This chapter deals with the methods for the syntheses of 2,5-dihydro-l,2-oxaphosphole-2-oxide derivatives, and some recent results of their biological activity testing. The electrophilic addition to 1,2-alkadiene- and alkatrienephospho-nate derivatives is one of the easiest and fruitful synthetic strategies for obtaining these compounds in preparative amounts. 

Synthesis and Biological Activity of 2,5-Dihydro-l,2-Oxaphosphole-2-Oxide Derivatives... 

In his approach toward selenium-containing heterocycles with potential biological activity, Abdel-Hafez reacted 2-amino-3-(4,5-dihydro-17/-imidazol-2-yl)-4,5,6,7-tetrahydro-l-benzoselenophene 297 with triethyl orthoformate and benzaldehyde to generate the tricyclic systems 296 and 298, respectively (Scheme 21) <2005RJ0396>. Similarly, reaction with carbon disulfide gave the corresponding thiourea 299. 

Pyridazines continued to play a central role in the construction of new biologically active compounds. 2,7-Dihydro-3//-pyridazino 5,4,3-17 acridin-3-ones were synthesized as cytotoxic agents <05BMC1969> and 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2//-... 

The hydrogenation of ketones with O or N functions in the a- or / -position is accomplished by several rhodium compounds [46 a, b, e, g, i, j, m, 56], Many of these examples have been applied in the synthesis of biologically active chiral products [59]. One of the first examples was the asymmetric synthesis of pantothenic acid, a member of the B complex vitamins and an important constituent of coenzyme A. Ojima et al. first described this synthesis in 1978, the most significant step being the enantioselective reduction of a cyclic a-keto ester, dihydro-4,4-dimethyl-2,3-furandione, to D-(-)-pantoyl lactone. A rhodium complex derived from [RhCl(COD)]2 and the chiral pyrrolidino diphosphine, (2S,4S)-N-tert-butoxy-carbonyl-4-diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine ((S, S) -... 

Pyrrolo[l,2-A]thiazoles are aromatic compounds but only one fully conjugated derivative has been described. A few dihydro and tetrahydro derivatives have been prepared, mainly in connection with search for biologically active drugs. Saturated compounds are also known. 

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