Iminosugars biological activity

M. S. J. Simmonds, G. C. Kite, and E. A. Porter, Taxonomic distribution of iminosugars in plants and their biological activities, in A. E. Stiitz, (Ed.), Iminosugars as Glycosidase Inhibitors, Wiley-VCH, Weinheim, New York, 1999, pp. 8-30. 

P. Compain, V. Desvergnes, V. Liautard, C. Pillard, and S. Toumieux, Tables of iminosugars, their biological activities and their potential as therapeutic agents, in P. Compain and O. R. Martin, (Eds.), Iminosugars From Synthesis to Therapeutic Applications, Wiley, Chichester, 2007, pp. 327 -55. 

Because they exhibit various fascinating biological activities [1], polyhydroxylated alkaloids that mimic sugar structure arouse a growing interest in the last few years. Naturally occurring iminosugars are classified in five structural families polyhydroxylated pyrrolidines, piperidines, indolizidines, nor-tropanes, and pyrrolizidines (fused pyrrolidines with N at the bridgehead) alkaloids [2]. The pyrrolizidine skeleton with a hydroxyl substituent at C-3 is relatively rare in Nature and appears to be restricted to specific families, while piperidine and pyrrolidine skeleton are conunon in many species. 

Simmonds MSJ, Kite GC, Porter EA (1999) Taxonomic distribution of iminosugars and their biological activities. In Stiitz AE (ed) Iminosugars as glycosidase inhibitors. Wiley-VCH, Weinheim, p 8... 

Whilst some early studies [85, 86] focused only on the difficult synthesis of iminosugar calixarene clusters, more recently preparation by CuAAC [87, 88] has allowed access to derivatives that could be assessed for their biological activity. 

Lundt I (2003) Iminosugars, isoiminosugars, and carbasugars from activated carbohydrate lactones efficient synthesis of biologically important compounds. In Witzak ZJ, Tatsuta K (eds) Carbohydrate synthons in natural products chemistry synthesis, functionalization and applications. ACS Symposium Series, vol 841. American Chemical Society, Washington, DC,pp 117-140... 

Iminosugars, Isoiminosugars, and Carbasugars from Activated Carbohydrate Lactones Efficient Synthesis of Biologically Important Compounds... 

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