IEUBK Biokinetic model

Pharmacokinetic models have been developed that attempt to relate environmental levels to PbB levels (Leggett 1993 O Flaherty 1995). The Integrated Exposure Uptake Biokinetic Model (IEUBK) developed by EPA is one of the most extensive efforts to date to make population-based predictions of PbB levels based upon environmental data. The model incorporates both exposure/uptake parameters and a biokinetic component to estimate the PbB distribution in the exposed population (EPA 1994). 

Species extrapolation. Data in both animals and humans (children and adults) describing the absorption, distribution, metabolism, and excretion of lead provide the biological basis of the biokinetic model and parameter values used in the IEUBK Model. The model is calibrated to predict compartmental lead masses for human children ages 6 months to 7 years, and is not intended to be applied to other species or age groups. 

Kinetic Constants and Model Parameters in the O Flaherty Model 2-7 Residence Times in the Biokinetic Module of the IEUBK Model 2-8 Kinetic Constants and Model Parameters in the Leggett Model 2-9 Summary of Blood Slope Factors from Various Environmental Media 2-10 Genotoxicity of Lead In Vivo 2-11 Genotoxicity of Lead In Vitro... 

The Integrated Exposure Uptake and BioKinetic (IEUBK) Model for Lead in Children is a classical... 

Table 2-7. Residence Times in the Biokinetic Module of the IEUBK Model...

Interroute extrapolation. The IEUBK Model includes an exposure module that simulates age-specific lead exposures via inhalation, and ingestion of lead in diet, dust, lead-based paint, soil, and water. The total exposure from each route is defined as the total lead uptake ( pg/day) over a 1-month period. Other routes of exposure may be simulated by the IEUBK Model pending available information from which to characterize both the exposure and media-specific absorption variables. Values for variables in the biokinetic component of the IEUBK Model are independent of the route of exposure. 

Exposure Uptake Biokinetic (IEUBK) model stochastic with probabilistic output sensitivity analysis lead exposure for children (6 months to 7 years old) across multiple pathways, routes, and environmental media, estimates blood lead concentrations (2005e)... 

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