Bioinformatics algorithm

The aim of the fust dimension breadth is to reveal sequence-function relationships by comparing protein sequences by sequence similarity. Simple bioinformatic algorithms can be used to compare a pair of related proteins or for sequence similarity searches e.g., BLAST (Basic Local Alignment Search Tool). Improved algorithms allow multiple alignments of larger number of proteins and extraction of consensus sequence pattern and sequence profiles or structural templates, which can be related to some functions, see e.g., under http //www. expasy.ch/tools/ similarity. 

Steffen Schulze-Kremer, Molecular Bioinformatics Algorithms and Applications, Walter de Gruyter, Berlin, 1996. 

Incogen is a life sciences software and services company. The Visual Integrated Bioinformatics Environment (VIBE), a visual programming and workflow platform, is one of their software offerings. The user can create workflows to import data from a number of sources and pass the data through common bioinformatics algorithms. 

Martin S (2010) Machine learning-based bioinformatics algorithms application to chemicals. Handbook of chemoinformatics algorithms. Chapman and Hall/CRC, Boca Raton,... 

A Zellner. An Introduction to Bayesian Inference in Econometrics. New York Wiley, 197L I Zhu, IS Em, CE Lawrence. Bayesian adaptive sequence alignment algorithms. Bioinformat-ics 14 25 -39, 1998. 

The functions of a large proportion of the proteins encoded by the human genome are presently unknown. Recent advances in bioinformatics permit researchers to compare amino acid sequences to discover clues to potential properties, physiologic roles, and mechanisms of action of proteins. Algorithms exploit the tendency of nature to employ variations of a structural theme to perform similar functions in several proteins (eg, the Rossmarm nucleotide binding fold to bind NAD(P)H,... 

The specificity determinants surrounding the tyrosine phospho-acceptor sites have been determined by various procedures. In PTK assays using various substrates, it was determined that glutamic residues of the N-terminal or C-terminal side of the acceptor are often preferred. The substrate specificity of PTK catalytic domains has been analyzed by peptide library screening for prediction of the optimal peptide substrates. Finally, bioinformatics has been applied to identify phospho-acceptor sites in proteins of PTKs by application of a neural network algorithm. 

Demirev, P. A. Lin, J. S. Pineda, F. J. Fenselau, C. Bioinformatics and mass spectrometry for microorganism identification Proteome-wide post-translational modifications and database search algorithms for characterization of intact H. Pylori. Anal. Chem. 2001, 73, 4566 573. 

Wei, Z. and Jensen, S.T., GAME Detecting cis-regulatory elements using a genetic algorithm, Bioinformatics, 22,1577,2006. 

Qin, Z. S., Gopalakrishnan, S., and Abecasis, G. R. (2006) An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria. Bioinformatics. 22, 220-225. 

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