Biogenic amine transporters

Rothman, R.B., Partilla, J.S., Baumann, M.H. et al. Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters a pharmacological strategy for treating stimulant abuse. Synapse. 35 222, 2000. 

Schuldiner, S., Steiner-Mordoch, S., Yelin, R., Wall, S.C., and Rudnick, G., Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters, Mol. Pharmacol. 44(6), 1227-1231, 1993. 

Blakely, R. D. and Bauman, A. L. (2000) Biogenic amine transporters regulation in flux. Curr. Opin. Neurobiol. 10, 328-336. 

Chiral protoalkaloids, such as cathinone (55), a psychotropic constituent of Catha edulis Forssk. (khat), have provided probes for studying the mechanistic properties of biogenic amine transporters, and afforded information regarding the effect of stereochemistry at the transportation level of these nitrogenous compounds. ... 

Rothman RB, Baumann MH, Targeted screening for biogenic amine transporters Potential applications for natural products, Life Sci 78 512-518, 2005. 

Drugs fall into one of three categories, targeting either G protein-coupled receptors, ionotropic receptors or ion channels, or biogenic amine transporters. 

Rudnick G, Steiner-Mordoch SS, Fishkes H, Stern-Bach Y, Schuldiner S (1990) Energetics of reserpine binding and occlusion by the chromaffin granule biogenic amine transporter. Biochemistry 29 603-608. 

Three-dimensional representation of VHD-associated and non-VHD-associated drug affinity for a battery of GPCRs, ligand-gated ion channels, and biogenic amine transporters. 

To date, neither the stoichiometry nor the electrogenicity of serotonin uptake has been resolved, the evidence gleaned from intact cells being different from that for isolated vesicle systems. A further complication to the study of biogenic amine transport is the fact that there are cellular granules which act as storage sites in neural cells (and other cells as well, e.g., platelets) so that a second level of transport occurs inside the cell. These intracellular granules have an ATP-ase which creates... 

Graham, D. Langer, S. (1992). Advances in sodium-ion coupled biogenic amine transporters. Life Sci. 51, 631-645. 

Hoffman BJ, Hansson SR, Mezey E, Palkovits M (1998) Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol 79 187-231. 

Gu. H. et al. (1994) Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence./. Biol. Chem., 269,7124-7130. 

---