3- , biofissionable

One or more biofissionable links, such as amide or ester groups, required for drug release in the biological environment, must be inserted into the spacer. At least one of these must be sufficiently remote from the main chain to permit enzyme approach for cleavage action. 

The macromolecular main chain should be rendered biodegradable through incorporation of biofissionable intrachain links, such as amide or urethan groups. The main chain and the spacers both should be nontoxic and should possess minimal immunogenicity. 

Intra- or extrachain solubilizing group = Biofissionable link... 

B. Slowly Biofissionable Pt-N Complexes Anchored through Primary and Secondary Amines... 

The transition between the so called slowly and readily biofissionable products is now discussed. Chitosan was employed in another study attempting to create water-soluble products that were biodegradable. " Chitosan is a polysaccharide with a structure similar to that of cellulose. Compoimd 29, is an abbreviated structure of some of the possible imit structures that include inter/intra-molecularly... 

The Pt-N polymer-metal interconnection in the structures covered in the previous section is generally tight-binding and not readily biofissionable. Therefore, in order to achieve faster release of the monomeric bioactive drug complex in the biological environment, the amino groups must be flanked or carrier-interconnected by bonds that are biocleavable and allow hydrolytic or enzymatic backbone or sidechain fragmentation with ultimate liberation of the monomeric complex entity. 

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