Biodevice system

To the best of our knowledge, no data are available about the thermal stability of H-terminated Si surfaces grafted with azido groups. However, the thermal stability study of the Si surfaces terminated by the simplest azido group, i.e., N, would be of high interest for further modifications for instance in the context of biodevice systems. It would be helpful for xmderstanding the mechanisms of surface reactions as well as for reaching a finer control of the surface at the atomic level. 

The advantage of usii RC biodevices mainly depends on the specificity of the enzyme to recognize certain analytes or particular physicochemical conditions. Moieover, RC and PSII are especially suitable because of their physiological activities that can be easily monitored by amperometric, po-tentiometric and optical systems (F. 1). 

The advantage of using photosyntheric and light-dependent protein biodevices depends on the enzyme specificity in recognizing certain analytes or particular physical chemical conditions. Moreover, their biochemical activities can be easily monitored by amperometric, potenziometric and optical systems. 

Chapter 2, by Ariga, Ji and Hill, presents recent developments on the application of the layer-by-layer technique for encapsulating enzymes. Encapsulation strategies are demonstrated for enzymes in both thin film and particle formats to generate complex enzyme architectures for microreactions. The integration of such systems into advanced biodevices such as microchannels, field effect transistors and flow injection amperometric sensors is also presented. 

Heller MJ, Tu E, Martinsons RR et al (2002) Active microelectronic array systems for DNA hybridization, genotyping, pharmacogenomics and nanofabrication applications. In Heller MJ, Guttmann A (eds) Integrated microfabricated biodevices. Dekker, New York, pp 223-270... 

Researchers in the field have overcome many of the limitations for real-life applications, but there are many others that are still to be overcome, specifically the stability of the biocatalyst, the biocompatibility of the materials and the products, the chemical and mechanical stability of the electrode materials, the electrolytic solution, and the packaging of the device. Recent advances in nanotechnology have brought great improvements to the development of composite nanomaterials that are feasible to be integrated into BFC designs. Better understanding of the enzymatic systems and processes certainly helped the development of biosensors and made us envision close future applications of BFCs for biomedical purposes. Furthermore, new alternatives for ex vivo applications of biodevices may be implemented in a shorter period of time. 

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