Biodegradable polyurethanes mechanical properties

Guelcher SA, Gallagher KM, Srinivasan A, McBride SB, Didier JE, Doctor JS, et al. Synthesis, in vitro biocompatibUity and biodegradation, and mechanical properties of two-component polyurethane scaffolds effects of water and polyol composition. Tissue Eng 2007 13(9) 2321-33. 

Yeganegi M, Kandel RA, Santerre JP (2010) Characterization of a biodegradable electrospun polyurethane nanofiber scaffold mechanical properties and cytotoxicity. Acta Biomater 6(10) 3847-3855... 

Guelcher, S. A., Srinivasan, A., Dumas, J. E., Didier, J. E., McBride, S., Hollinger, J. 0. (2008). Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates, Rinmat.p.rials. 29,1762-1775. 

Z. Ma, Y. Hong, D. Nelson, J. Pichamuthu, C. Leeson, W. Wagna-, Biodegradable polyurethane ureas with variable polyesto" or polycarbonate soft segments effects of crystallinity, molecular weight, and composition on mechanical properties. Biomacromolecules 12 (9) (2011) 3265-3274. 

S. Dutta, N. Karak, J. P. Saikia and B. Konwar, Biocompatible epoxy modified bio-based polyurethane nanocomposites mechanical property, cytotoxicity and biodegradation , Bioresour Technol, 2009,100, 6391-7. 

Epoxy-modified Mesua ferrea L. seed oil-based polyurethane/clay nanocomposites at different loadings (1-5 wt%) have been studied as biocompatible biomaterials. The partially exfoliated nanocomposites were prepared by an ex situ solution technique under high mechanical shearing and adequate ultrasonication at room temperature. The nanocomposites exhibited enhanced mechanical properties such as tensile strength (twofold) and scratch hardness (five-fold), thermostability (to about 40°C), and an increase in the rate of biodegradation between five- and ten-fold. All the nanocomposites showed RBC haemolysis inhibition observed by anti-hemolytic assay carried out on the sterilised films. 

---