Biodegradable polyurethanes dermal substitutes

From the outset it was necessary that any biodegradable polyurethane intended for use as a dermal substitute would need to be nontoxic to cells (noncytotoxic) and support the growth of fibroblasts (and their production of collagen) and keratinocytes. Ultimately, in the wound, the matrix would need to sustain blood vessel in-growth to supply the overlying skin-grafted epidermis with nutrients, oxygen, immune cells, and factors, and transport out the toxic by-products of cellular respiration. Therefore, microvascular endothelial cells (MVECs) would also need to thrive in the presence of BTM. 

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