Bioconjugate biological properties

Licha K, Hessenius C, Becker A, Henklein P, Bauer M, Wisniewski S, Wiedenmann B, Semmler W (2001) Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes. Bioconjugate Chem 12 44—50... 

D. Page and R. Roy, Synthesis and biological properties of mannosylated starburst Poly(amidoamine) dendrimers, Bioconjug. Chem., 8 (1997) 714—723. 

The high efficiency and simplicity of CuAAC methodology made this reaction suitable for the development of new nucleoside bioconjugates with novel or increased biological properties, altered hydrophobicity, increased bioaffinity, or ability to carry metal ions. 

The advantage of the click reaction for bioconjugation is that the reactant pair is not reactive with any other functional group encountered in biological systems. This property of... 

Of all the fullerene forms, the nearly spherical properties of C o have attracted the greatest attention, especially in the field of bioconjugation. In addition to its physical properties, C o fullerenes have unique photo-optical and electro-chemical properties, which make them useful as carriers for biomedical research applications. For instance, upon exposure to light C o will generate singlet oxygen, which can be used in vivo to cleave biological molecules, particularly DNA and RNA. Studies indicate that irradiation of Cgo in solution can be used to destroy virus contamination (Kasermann and Kempf, 1997). Solutions of Buckminsterfullerene are a deep purple color, whereas other sizes of fullerenes display a variety of other colors. 

Bae Y, Nishiyama N, Fukushima S, Koyama H, Yasuhiro M, Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjugate Chem 2005 16 122-130. 

Rebizak, R., Schaefer, M. and Dellacherie, E., 1998, Polymeric conjugates of Gd diethylenetriamine pentaacetic acid and dextran 2. Influence of spacer arm length and conjugate molecular mass on the paramagnetic properties and some biological parameters. Bioconjug. Chem., 9 94-99... 

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