Biocompatible scaffolds

Biocompatible scaffold incorporating growth factor-encapsulated nanoparticles... 

Later, Rinki et al. proposed a green approach to prepare nanoscaffolds from CHNCs using supercritical carhon dioxide (scCOa). The scCOa method was found to be more time and energy efficient, with improved scaffold properties compared to the lyophilization method. An increase in surface area, pore volume, and pore size confirmed formation of the network structure. This type of highly porous biocompatible scaffold is an attractive material for tissue engineering applications. Lertwattanaseri et al. also reported a microwave technique for the preparation of a chitosan scaffold from chitin nanocrystals. 

Different biomaterials have been tested in combination with MSCs for developing engineered tissues and delivering cells and/or drugs for in vivo applications. Here we briefly review the main materials used to construct biocompatible scaffolds and their combination with cationic polymers, with particular emphasis on chitosan. 

Wang H, Feng Y, Fang Z, Yuan W, Khan M. Co-electrospun blends of PU and PEG as potential biocompatible scaffolds for small-diameter vascular tissue engineering. Mater Sci Eng C 2012 32(8) 2306-15. 

Das B, et al. Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissne engineering. J Mater Chem B 2013 1(33) 4115-26. 

In aqueous media diverse dynamic polymeric networks and assemblies have been developed using the inclusion complex-forming competency of CDs as a noncovalent binding motif. These polymeric systems have been explored for biomedical applications like sustained and targeted release of APIs, medical diagnostics and tissue engineering (biocompatible scaffolds). 

Results suggesting that PANi- Li, M. Y., et al. (2006) gelatin blend nanofibers might provide a novel conductive material that is also a biocompatible scaffold for tissue engineering, reported. 

The ability to pattern 3D biocompatible scaffolds may lead to new fundamental understanding of tissue development and remodeling as well as the formation of multi-cellular aggregates in complex micro-environments that better mimic the targeted tissues of interest. Using direct-write assembly, 3D silk scaffolds for tissue... 

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