Poly biocompatibility

Implants in the rabbit corneas exhibited no observable inflammatory characteristics over a period of 6 weeks. Compared to other previously tested polymers, the inertness of these polyanhydrides rivals that of the biocompatible poly(hydroxyethyl methacrylate) and ethylene-vinyl acetate copolymer. Histological examination of the removed corneas also revealed the absence of inflammatory cells (21)... 

Research Focus Synthesis of biocompatible poly(ester-amides) containing linear a-amino... 

Williams et al. (2) prepared biocompatible poly-co-hydroxyalkanoates, (I), containing long and short alkyl pendants that were used as sutures, rivets, tacks, staples, and screws in humans. 

Di-[di-(trimethylsilyl)amine]stannate has been used to prepare biocompatible poly (lactide-co-glycolide) containing up to an 88% lactide composition. When the molar ratio of catalyst/lactide was 41.9 17.9, respectively, apolymer was formed which had a molecular weight of 164,700 daltons having a polydispersity of 1.8. AU other ratios generated molecular weights less than 78,000 daltons. 

Shan, C., Yang, H., Han, D., Zhang, Q., Ivaska, A., and Niu, L. (2009). Water-soluble graphene covalently functionalized by biocompatible poly-L-lyslne. Langmuir, 20, pp. 12030-12033. 

Eldridge, J. H., Staas, J. K., Meulbroek, J. A., Tice, T. R. and Gilley, R. M., Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun., 59, 2978-2986 (1991). 

ICAO Cao, Y. and He, W., Functionalized biocompatible poly(V-vinyl-2-caprolactam) with pH-dependent lower critical solution temperatme behaviors, Macromol. Chem. Phys., 212, 2503,2011. 

EO leong, N.S., Redhead, M., Bosquillon, C., Alexander, C., Kelland, M., and O Reilly, R.K., The missing lactam - thermoresponsive and biocompatible poly(A-vinyl-piperidone) polymers by xanthate-mediated RAFT polymerization. Macromolecules, 44, 886, 2011. 

Fig. 2. Typical normalized intensity-intensity time correlation function for thermally sensitive and biocompatible poly(JV-vinyl caprolactam) (Afw = 2.34 x 10 g/mol, = 79 nm, and A2 = 1.59 x 10 mol-mL/g ) in water at 25°C.

While poly(ethylene oxide) (PEO) has high hydrophilicity and biocompatibility, poly(A-isopropyl acrylamide) (PNIPAM) is a well-known thermosensitive polymer having a low critical solution temperature in water at 32° C. Block copolymers containing PEO and PNIPAM are therefore expected to... 

W. Wang, Y. Guo, J.U. Otaigbe, Synthesis and characterization of novel biodegradable and biocompatible poly(ester-urethane) thin films prepared by homogeneous solution polymerization, Polymer 49 (2008) 4393-4398. 

Rana S, Lee SY, Cho JW. Synthesis and characterization of biocompatible poly(ethylene glycol)-functionalized polyurethane using click chemistry. Polym Bull 2010 64 401-11. 

LAU Lau, A.C.W. and Wu, C., Thermally sensitive and biocompatible poly(A-vinylcaprolactam) synthesis and characterization of high molar mass linear chains. Macromolecules, 32, 581, 1999. 

Quan, C., Wei, H., Sun, Y., Cheng, S., Chen, K., et al. 2008. Polyethylenimine-modified biocompatible poly(V-isopropylacrylamide)-based nanogels for drug delivery. J. Nanosci. Nanotechnol. 8 ... 

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