Pancreas, bioartificial

Sakai, S., Ono, T., Ijima, H. and Kawakami, K. (2001) Synthesis and transport characterization of alginate/ aminopropylsilicate/alginate microcapsule application to bioartificial pancreas. Biomaterials, 22, 2827-2834. 

Teramura Y, Iwata H (2010) Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans. Adv Drug Deliv Rev 62 827-840... 

Keywords Bioartificial pancreas, biomaterials, complex coacervation, immunoisolation, microencapsulation, polyelectrolytes, water soluble polymers... 

The principle of a bioartificial pancreas design is presented in figure 11. 

Figure 11. Scheme of a bioartificial pancreas surrounded by a hydrogel membrane [266], Some methods used for artificial organs design are presented in table 17. 

Kizilel S, Garfinkel M, Opara E. The bioartificial pancreas progress and challenges. Diabetes Technol Ther. 2005 7 968-985. 

In Type-I diabetes, which is due to the loss of insulin-producing cells as a consequence of autoimmune disorders, substitution of insulin is the most important measure. However, merely to inject one daily dose is not an adequate therapy. Here, the objective is to mimic the daily variations in plasma insulin which are closely related to food intake. One such attempt which has improved microvascular complications is intensified insulino-therapy through multiple daily injections of insulin. Another approach is to develop techniques of islet transplantation and using a bioartificial pancreas. In the case of islet transplantation, tissues will not only respond to changes in blood glucose levels but also to hormones of the entero-insular axis. 

Iwata H, Kobayashi K, Takagi T, Oka T, Yang H, Amemiya H, Tsuji T, Ito F. Feasibility of agarose microbeads with xenogeneic islets as a bioartificial pancreas. J Biomed Mater Res 1994 28 1003-1011. 

Sun, A. O Shea, G. Goosen, M. Injectable microencapsulated islet cells as a bioartificial pancreas. Appl. Biochem. Biotechnol. 1984,10 (1), 87-99. 

Benson, J. P., Papas, K. K., Constantinidis, I., Sambanis, A. Towards the development of a bioartificial pancreas Effects of poly-L-lysine on alginate beads with BTC3 cells. Cell Transplant. 1997,6,395—402. 

M.V. Risbud, R.R. Bhonde, Suitability of cellulose molecular dialysis membrane for bioartificial pancreas in vitro biocompatibility studies, J. Biomed. Mater. Res. 54 (3) (2001) 436 44. 

DMAAm MA-PIB-MA Free radical Permeability tests Bioartificial pancreas 51... 

Bugarski, M.B., Sajc, L., Plavsic, M., Goosen, M.F.A., and Jovanovic, G., Semipermeable alginate-PLO microcapsules as a bioartificial pancreas, in Animal Cell Technology, Basic and Applied Aspects, Vol. 8, Funatsu, K., Shirai, Y., and Matsushita, T., Eds., Kluwer Academic Publishers, Dordrecht, 1997, pp. 479-486. 

Zhou D., Kintsourashvili E., Mamujee S., Vacek 1., Sun A.M., Bioartificial pancreas Altemative supply of insulin-secreting cells, in Bioartificial organs II. Technology, medicine materials, Eds. Hunkeler D., Prokop A., Cherington A.D., Rajotte R. V., and Sefton M., Annals of the New York Academy of Sciences, New York Arm. NY. Acad. Sci. 875, 1999, pp. 208-218. 

Generalities, Methods, Applications and Bioartificial Pancreas Case Study... 

Small capsule diameters to ensure sufficient diffusion and internal organ tiansplantability (depending on application, < 400 pm for bioartificial pancreas), with the cell centering within the microcapsule... 

Zhou D, Kintsourashvili E, Mamujee S et al. Bioartificial pancreas Alternative supply of insulin-secreting cells. Ann NY Acad Sci 1999 875 208-218. 

Mikos AG, Papadaki MG, Kouvroukoglou S et al. Islet transplantation to create a bioartificial pancreas. Biotechnol. Bioeng 1994 43 673-677. 

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