Bioactive sol-gel glass

Vallet-Regi, M., Salinas, A.J., Ramirez-Castellanos, J. and Gonzalez-Calbet, J. M. (2005) Nanostructure of bioactive sol-gel glasses and organic inorganic hybrids. Chemistry of Materials, 17, 1874-1879. 

Biocompatibility is actually a major problem for implants and bioactive sol-gel glasses have been developed. They are typically made of a mixture of silica and calcium phosphate in order to show some affinity for the in vitro and in vivo nucleation of apatite (Hench, 1998). Such sol-gel glasses can also be used as implantable drug carriers. Experiments performed with ibuprofen, an anti-inflammatory drug, show that both processes, formation of an apatite layer and drug release, occur simultaneously. The release kinetics is mainly influenced by the solubility of the drug and the pore size of the bioglass (Ramila, 2003 Hall, 2003). 

Figure 43.2 (a) Scanning electron microscope image of a bioactive sol-gel glass monolith made under acid catalysis. (Courtesy of Sen Lin.) (b) Transmission electron microscope image of bioactive glass submicron particles. (Modified with permission from Ref [25].)... 

Ramila, A., Balas, F., and Vallet-Regi, M. (2002) Synthesis routes for bioactive sol-gel glasses alkoxides versus nitrates. Chem, Mater., 14, 542-548. 

Fig. 12.14 Mechanical parameters calculated by nano-indenta-tion tests for a conventional sol—gel glass and two different bioactive star gels with analogous Ca/Si molar ratio.

Salinas, A.J., Merino, J.M., Hijon, N., Martin, A.I. and Vallet-Regi, M. (2004) Bioactive organic-inorganic hybrids based on CaO-Si02 sol-gel glasses. Key Engineering Materials, 254-256, 481-484. 

D. Avnir, S. Braun, and M. Ottolenghi, The Encapsulation of Organic Molecules and Enzymes in Sol-Gel Glasses Novel Photoactive, Optical, Sensing and Bioactive Materials. A Review. National Technical Information Service (NTIS) Publication No. AD-A224 154, 21 pp. (1991). 

Martin RA, Yue S, Hanna JV, Lee PD, Newport RJ, Smith ME, Jones JR (2012) Characterizing the hierarchical structures of bioactive sol-gel silicate glass and hybrid scaffolds for bone regeneration. Philos Trans Ser A Mathemat Phys Eng Sci 370(1963) 1422-1443... 

Vallet-Regi, M Salinas, A.)., Roman,). and Gil, M. (1999) Effect of magnesium content on the in vitro bioactivity of Ca0-Mg0-Si02-P20s sol-gel glasses. Journal of Materials Chemistry, 9(2), 515-18. 

Enzymes Immobilized in Sol-Gel Glass Matrices Bioactive Glasses... 

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