Bioactive polyketides

Motivated by the value of these natural products, there has been much research focused on developing guidelines for engineering polyketide synthases to generate natural and novel polyketides [445,446], Additionally, manipulation of the biosynthetic pathways of microbial polyketides through engineering permits the biosynthesis of bioactive polyketides not generated naturally [447,448],... 

Total Stereoselective Synthesis of Acetogenins of Annonaceae A New Class of Bioactive Polyketides... 

Analogous treatment of the unsaturated ester 207 using 1,1-dibromoethane in this case cleanly produced the dihydropyran 208 in high yield on a gram scale (Scheme 2.73) [41bj. Cydic enol ether 208 was then efficiently advanced to a spiroacetal, which corresponds to the core structure of the bioactive polyketide spirofungin A. 

Berrue, F., Thomas, O.P., Laville, R., Prado, S., Golebiowski, J., Fernandez, R., and Amade, P. (2007) The marine sponge Plakortis zyggompha a source of original bioactive polyketides. Tetrahedron, 63, 2328-2334. 

Jimenez, M. del Sol, Garzon, S.P., and Rodriguez, A,D, (2003) Plakortides M and N, bioactive polyketide endoperoxides from the Caribbean marine sponge Plakortis halichondrioides. J. Nat. Prod., 66, 655-661,... 

Yoon, Y.J., Beck, B.J., Kim, B.S. et al. (2002) Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry Biology, 9, 203-214. 

Jung WS, Lee SK, Hong JSJ, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG Choi CY, Sherman DH, Yoon YJ. (2006) Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol 72 763-769. 

Kobayashi J, Kubota T. Bioactive macrolides and polyketides from marine dinoflagellates of the genus Amphidinium. J. Nat. Prod. 2007 70 451-460. 

Over the past quarter-century more than 10,000 compounds have been reported from marine-derived organisms. These compounds encompass a wide variety of chemical structures including acetogenins, polyketides, terpenes, alkaloids, peptides and many compounds of mixed biosynthesis. A number of excellent books and reviews document the diversity of both structures and bioactivities which have been observed for marine-derived compounds. ... 

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