Bio-inorganic chemistry

Thousands of examples of the HSAB concept that strong bonds are only formed between hard-hard or soft-soft components have been 

Conversely, very non-poisonous or inert metals are needed when artificial prostheses have to be introduced during surgery and so metals which, if dissolved, would give soft ions are chosen, e.g. gold, silver, tantalum, and platinum or their alloys. Because they give soft ions there is negligible tendency for those metals to give up electrons to form soft metal ion—hard solvent bonds (water is hard). 

The first part of this section considers those studies related to zinc metalloenzymes and to the interaction of the metals with other proteins and nucleic acids the second part considers the uses of organomercurials. The same format as last year has been followed, except for the exclusion of the section considering the environmental effects of the metals and organomercurials. 

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By far the most utilized Mossbauer isotope is Fe, particularly in (bio)inorganic chemistry. Most iron compounds are found in the oxidation states iron(ll) and iron (III), either with low-spin or high-spin electron configuration. The literature on the application of Fe Mossbauer spectroscopy in this field of research has been reviewed in several textbooks, which are referenced in Chap. 1. The present chapter is intended as a survey of the Mossbauer studies on iron compounds with less common, nevertheless increasingly interesting, valence and spin states. 

Hay, R. W. Bio-Inorganic Chemistry, Ellis Horwood Limited, Halsted Press, New York, 1984. 

Mardniec, B., Pawluc, P. and Pietraszuk, C. (2007) Inorganometallic Chemistry, in Inorganic and Bio-Inorganic Chemistry, Encyclopedia of Life Support Systems (ed. I. Bertini), Developed under the Auspices of UNESCO, EOLSS Publishers Co. Ltd, Oxford, UK www.eols.net. 

In summary, by combining the information obtained from the new mixed-metal clusters with the progress made in describing the spin coupling of delocalized mixed valence dimm with double exchange, we can anticipate new insight into the electronic structure of many clusters of interest in bio-inorganic chemistry. 

Bio-inorganic Chemistry What Is it, and What s So Exciting Overview (Valentine and O HaUoran, 1999)... 

K. N. Raymond, Bio-inorganic Chemistry II , ACS Advances in Chemistry, Series No. 162, American Chemical... 

The Shannon-Prewitt tabulation also distinguishes between different spin states for ions of the transition elements. For example, the radius of Fe2+ in octahedral six-coordination is 17 pm smaller for the low-spin state as opposed to high-spin. If you study bio-inorganic chemistry in a more advanced text, you will find that this fact is of great importance in understanding the mechanics of the haemoglobin molecule (see Section 9.8). 

In addition to relevant chapters in inorganic texts, see the books listed in Section A.9 of the Appendix. An interesting account of donor/ acceptor interactions is given by Gutmann, V. (1978). The Donor-Acceptor Approach to Molecular Interactions. New York Plenum. For bio-inorganic chemistry, see the book by Hughes (1982) cited in Section A.12. For Sections 9.6 and 9.7, Cotton and Wilkinson s (1988) text (Section A.3) should be consulted. 

A separate section, compiled by Martin Hughes of the University of Cambridge, reviews advances in the bio-inorganic chemistry of the Group IIB elements, and reflects the rapid growth of interest in this area in recent years. 

Ochaia, E-I., Bio-Inorganic Chemistry An Introduction, Allyn and Bacon, Boston, 1977. 

Fiabane, A.M. and Williams, D.R., The Principles of Bio-Inorganic Chemistry, Chemical Society Monographs, Vol. 31, Chemical Society, London, 1977. 

A109. G. Eichhorn, ed., Inorganic Biochemistry. Elsevier, Amsterdam, 1972. Topics covered include bio-inorganic chemistry of nitrogen fixation. 

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