Bio-based green solvent

In addition, bio-based green solvents can be generated from PHAs after their utilization via pyrolysis. This way, unsaturated compounds such as crotonic acid and 2-pentenoic acid needed for synthesis of lactones are generated. 

Reaction conditions Ethyl lactate-water system (as a bio-based green solvent), room temperature... 

Keywords Isatins, naphthaquinone, proline, ethyl lactate-water system, bio-based green solvent, room temperature, 1,3-dipolar cycloaddition, one-pot three-component reaction, spiro-oxindoles, spiro[benzo[/]pyrrolo[2,l-fl]isomdole-5,3 -indoline]-2, 6,ll-triones... 

Dandia, A., Jain, A. K., and Laxkar, A. K. (2013). Ethyl lactate lactate as a promising bio based green solvent for the synthesis of spiro-oxindole derivatives via 1,3 dipolar cycloaddtion reaction. Tetrahedron Lett., 54, 3929-3932. 

Just taking a quick look at the different chapters, one can realize which areas of each field are mature and which can evolve immediately. Although it is very difficult to venture a general trend for the whole area, we could emphasize that there is not a tmly enantioselective version for the mono-activated hydrogen autotransfer reaction. The use of first-row transition metals is almost an unexplored Blue Ocean , in all aspects. Furthermore, the possible impact of green neoteric solvents, including deep eutectic mixtures, supercritical fluids, and bio-based solvents, on the hydrogen transfer process is definitely unknown. 

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