Binding functional groups

THE PREPARATION AND FUNCTIONALISATION OF (VINYL)POLYSTYRENE POLYHIPE. SHORT ROUTES TO BINDING FUNCTIONAL GROUPS THROUGH A DIMETHYLENE SPACER... 

Short Routes to Binding Functional Groups through a Dimethylene Spacer 125 A. Mercier, H. Deleuze, B. Maillard and O. Mondain-Monval... 

Uranium-binding functional groups have been selected according to their ability to displace the carbonate ions in [UCy CC ]4- at the pH of natural sea water. The classes of compounds compiled in Table 4 proved to be effective U9-130). 

The stereochemistry of the metal ion-binding functional groups in the protein must satisfy the coordination geometry of the metal ion to be used. This requires that the appropriate number of protein side chains or solvent molecules be placed around the metal ion, that they be placed at the appropriate bond distances and angles, and that they be in the correct overall coordination geometry. 

Rhodanine by-products have been used as antiviral, antibacterial, antihistaminic and anticorrosion agents [34, 35]. Additionally, they have also been used to identify metal ions as the rhodanine molecule has metal-binding functional groups, such as thioamide and amide [36, 37]. It is thought that the improved antimicrobial efficacy of the silver/polyrhodanine nanofibres is due to the joint antimicrobial activity of silver and polyrhodanine nanofibres. Silver NP-embedded polyrhodanine nanofibres can be prepared via chemical oxidation polymerisation. 

Metalloporphyrins act as the catalytic reaction center and/or the Lewis acid site to bind functional groups of guest molecules. 

Covalent chromatography Covalent binding Functional groups... 

There have been a number of different approaches used for obtaining the mixed SAMs. The simplest approach is the formation of a monolayer via deposition of a substrate in a mixed solution that contains an active (containing the binding functional group) and inert surfactant (acts as the spacer to distribute the functional group in the first surfactant). This method is simple, but has some limitations such as the fact that the ratio of active surfactants in the monolayer is rarely identical to the ratio of active surfactants in the solution due to the preferential adsorption of one of the components, thus affecting control over the... 

Typically, HDAC enzyme inhibitors are substrate mimics that can be described by a pharmacophore consisting of a warhead, spacer and cap. The warhead is a reversible zinc binding functional group while the spacer occupies the hydrophobic substrate binding tunnel. At the other end of the molecule is the cap that serves to mimic the rest of the protein substrate and forms binding interactions with the surface exposed rim of the HDAC. The zinc binding warhead is often a hydroxamic acid, ever since HDAC inhibition was demonstrated by Yoshida to be the molecular target of the natural... 

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